Esketamine is the S-enantiomer of ketamine and is FDA-approved for treatment-resistant depression when administered intranasally under medical supervision. It is approximately 4 times more potent at NMDA receptors than the R-enantiomer and approximately 2 times more potent than racemic ketamine. Side effects include dissociation, dizziness, sedation, increased blood pressure, and nausea. Contraindicated in individuals with aneurysmal vascular disease, uncontrolled hypertension, or history of psychosis. Available only through REMS program (Spravato REMS) in the US.
Esketamín molecular structure diagram from the DrugsPRO substance library.
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Esketamine - DrugsPRO sprievodca látky
Esketamine: Esketamine is the S-enantiomer of ketamine and is FDA-approved for treatment-resistant depression when administered intranasally under medical supervision. It is approximately 4 times more potent at NMDA receptors than the R-enantiomer and approximately 2 times more potent than racemic k
