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FXE

CRITICAL WARNING: True FXE (3'-Fluoro-2-oxo-PCE, 3-FXE) may have NEVER been available on the recreational market. In April 2023, DrugsData.org revealed that ALL samples they previously identified as FXE actually contained 2F-NENDCK (CanKet, 2'-Fluoro-2-oxo-PCE), a positional isomer differing only by fluorine position on the phenyl ring. True 3-FXE and 2F-NENDCK are nearly impossible to distinguish without advanced analytical methods like NMR spectroscopy. Most user reports, dosage information, and effects attributed to FXE from 2017-2023 were likely describing 2F-NENDCK experiences. As of 2024-2025, some vendors claim to sell true 3-FXE, but independent laboratory verification is essential.

FXE molecular structure
FXE molecular structure diagram from the DrugsPRO substance library.

Also known as: 3-fxe, 3f-o-pce, Fluorexetamine, 3'-fluoro-2-oxo-pce, Fluorexetamin

Classification

  • Chemical: Arylcyclohexylamine
  • Psychoactive: Dissociative
  • Tag: Hallucinogen
  • Tag: Research-Chemical

Effects

  • Analgesia
  • Pain Relief
  • Incoordination
  • Sedation
  • Nystagmus
  • Numbness
  • Dissociation
  • Motor Control Loss
  • Cognitive Impairment
  • Anxiety Suppression
  • Conceptual Thinking
  • Confusion
  • Tactile Suppression
  • Visual Distortion
  • Double Vision
  • Pattern Recognition Suppression
  • Perception Of Bodily Lightness
  • Open Eye Visuals

Routes of Administration

Oral

Dosage

  • Heavy: 60+ mg
  • Light: 10–20 mg
  • Common: 20–40 mg
  • Strong: 40–60 mg
  • Threshold: 5–10 mg

Duration

  • Onset: 0.25-0.5 h
  • Peak: 1-3 h
  • Offset: 2-3 h
  • After Effects: 6-24 h
  • Total Duration: 4-6 h

Insufflated

Dosage

  • Heavy: 50+ mg
  • Light: 8–15 mg
  • Common: 15–30 mg
  • Strong: 30–50 mg
  • Threshold: 3–8 mg

Duration

  • Onset: 0.08-0.25 h
  • Peak: 1-2.5 h
  • Offset: 1.5-2.5 h
  • After Effects: 4-24 h
  • Total Duration: 3-5 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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FXE - DrugsPRO sprievodca látky

FXE: CRITICAL WARNING: True FXE (3'-Fluoro-2-oxo-PCE, 3-FXE) may have NEVER been available on the recreational market. In April 2023, DrugsData.org revealed that ALL samples they previously identified as FXE actually contained 2F-NENDCK (CanKet, 2'-Fluoro-2-oxo-PCE), a positional isomer differing on

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