Library
O-DSMT
O-DSMT is the primary active metabolite of tramadol and is considerably more potent (2-4 times). Unlike tramadol, it lacks significant serotonin reuptake inhibition and has reduced seizure risk, though caution remains warranted. Appears as a research chemical with no approved medical use in most countries. Risk of respiratory depression and overdose, especially when combined with other CNS depressants. Potency varies significantly between batches in unregulated markets.
Also known as: O-Desmethyltramadol, Odt, O-smt, Desmetramadol
Classification
- Chemical: Opioid
- Psychoactive: Depressant
- Tag: Habit-Forming
- Tag: Phenylpropylamine
- Tag: Research-Chemical
- Tag: Sedative
- Tag: Synthetic opioid
- Tag: Tentative
Effects
- Pain Relief
- Physical Euphoria
- Itchiness
- Respiratory Depression
- Cough Suppression
- Difficulty Urinating
- Cognitive Euphoria
- Anxiety Suppression
- Compulsive Redosing
- Euphoria
- Mood Lift
- Dream Potentiation
- Decreased Libido
- Appetite Suppression
- Orgasm Suppression
- Dulled Perception
- Blurred Vision
- Disinhibition
Routes of Administration
Oral
Dosage
- Heavy: 100 mg
- Light: 10 – 25 mg
- Common: 25 – 50 mg
- Strong: 50 – 100 mg
- Threshold: 5-10 mg
Duration
- Onset: 0.33-1 h
- Comeup: 0.5-0.7 h
- Peak: 2-5 h
- Offset: 2-4 h
- After Effects: 6-14 h
- Total Duration: 4-8 h
Intravenous
Dosage
- Threshold: 5 mg
- Heavy: 50 mg
- Common: 12.5-25 mg
- Light: 5-12.5 mg
- Strong: 25-50 mg
Duration
- Onset: 0 h
- Peak: 2-5 h
- Offset: 2-4 h
- After Effects: 1-3 h
Sublingual
Dosage
- Threshold: 5 mg
- Heavy: 80 mg
- Common: 25-50 mg
- Light: 10-25 mg
- Strong: 50-80 mg
Duration
- Onset: 0.3-0.7 h
- Peak: 2-5 h
- Offset: 2-4 h
- After Effects: 1-3 h
Insufflated
Dosage
- Threshold: 5-10 mg
- Light: 10-25 mg
- Common: 25-50 mg
- Strong: 50-80 mg
- Heavy: 80+ mg
Duration
- Onset: 0.17-0.5 h
- Comeup: 0.25-0.5 h
- Peak: 0.75-2 h
- Offset: 2-4 h
- After Effects: 1-12 h
- Total Duration: 3-6 h
Rectal
Dosage
- Threshold: 5-10 mg
- Light: 10-25 mg
- Common: 25-50 mg
- Strong: 50-75 mg
- Heavy: 75 mg
Duration
- Onset: 0.25-0.75 h
- Comeup: 0.33-0.67 h
- Peak: 1.5-3 h
- Offset: 3-5 h
- After Effects: 1-12 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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