Ephenidine is a dissociative anesthetic of the diarylethylamine class that acts as an NMDA receptor antagonist. It emerged on research chemical markets in early 2015 and has been sold online as a designer drug. Structurally related to diphenidine and MXP, ephenidine is widely reported to produce a smoother dissociative experience compared to those compounds. Very little is known about this substance, and considerable caution is warranted given the limited safety data available.
Efenidin molecular structure diagram from the DrugsPRO substance library.
Also known as: Epe, Nedpa, DPD-E, N-ethyl-1,2-diphenylethylamine
Classification
Chemical: Diarylethylamine
Psychoactive: Dissociative
Tag: Habit-Forming
Tag: Hallucinogen
Tag: Research-Chemical
Tag: Tentative
Effects
Tactile Disconnection
Spontaneous Tactile Sensations
Stimulation
Increased Heart Rate
Pain Relief
Somatic Lightness
Depersonalization
Derealization
Consciousness Disconnection
Memory Suppression
Thought Deceleration
Information Processing Suppression
Disinhibition
Tactile Suppression
Hallucinations
Visual Drifting
Scenery Slicing
Internal Hallucination
Routes of Administration
Oral
Dosage
Heavy: 200 mg+
Light: 50 – 110 mg
Common: 110 – 150 mg
Strong: 150 – 200 mg
Threshold: 15–25 mg
Duration
Onset: 0.17-0.5 h
Peak: 2-4 h
After Effects: 6-24 h
Offset: 3-6 h
Total Duration: 4-8 h
Rectal
Dosage
Heavy: 150 mg+
Light: 15–35 mg
Common: 35–90 mg
Strong: 90–150 mg
Threshold: 10 mg
Duration
Onset: 0.17-0.5 h
Peak: 0.75-2 h
Offset: 2-4 h
After Effects: 4-20 h
Total Duration: 3-7 h
Insufflated
Dosage
Heavy: 150 mg+
Light: 15–40 mg
Common: 40–100 mg
Strong: 100–150 mg
Threshold: 5–15 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Ephenidine - DrugsPRO vodič po substancah
Ephenidine: Ephenidine is a dissociative anesthetic of the diarylethylamine class that acts as an NMDA receptor antagonist. It emerged on research chemical markets in early 2015 and has been sold online as a designer drug. Structurally related to diphenidine and MXP, ephenidine is widely reported to
