Fenelzin

Phenelzine is a non-selective, irreversible MAOI used for treatment-resistant depression, atypical depression, panic disorder, and social anxiety disorder. It requires strict dietary restrictions to avoid hypertensive crisis from tyramine-containing foods (aged cheeses, cured meats, fermented foods, certain alcoholic beverages). Numerous drug interactions can be life-threatening - a 14-day washout period is required when switching to or from other antidepressants. Not recommended for use with other serotonergic or adrenergic drugs. Vitamin B6 supplementation (pyridoxine form) may be needed due to enzyme interactions.

Also known as: Nardil, Kalgan, Monofen, Fenelzin, Stinerval, Β-phenylethylhydrazine, Phenelzinum, W-1544a

Classification

Chemical: Medicine
Tag: Antidepressant
Tag: Hydrazine derivative
Tag: MAOI

Effects

Sedation
Insomnia
Orthostatic Hypotension
Weight Gain
Dry Mouth
Fatigue
Mood Lift
Anxiety Suppression
Cognitive Enhancement
Dizziness
Euphoria
Anxiety
Appetite Suppression
Sexual Dysfunction
Light Sensitivity
Dulled Perception
Disinhibition
Tactile Suppression

Routes of Administration

Oral

Dosage

Light: 15 mg/day
Common: 30-60 mg/day (divided doses)
Strong: 90 mg/day (maximum recommended)
Heavy: Above 90 mg/day (not recommended)

Duration

Onset: 1-2 h
Comeup: 2-4 h
Peak: 2-4 h
Offset: 2 h
After Effects: 1-2 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

dose.wiki

Links

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