Дименхидринат

Dimenhydrinate is an over-the-counter first-generation antihistamine composed of diphenhydramine and 8-chlorotheophylline in a 1:1 salt form. Introduced in 1949 by G.D. Searle, it is primarily used to prevent motion sickness and nausea, a therapeutic application discovered accidentally during antihistamine research. At higher doses, dimenhydrinate produces deliriant effects characterized by dysphoric, realistic hallucinations, functioning at roughly half the potency of diphenhydramine alone.

Also known as: Dime, Drama, Drams, Gravol, Dimate, Vomex A, Driminate, Triptone, Dinate, Diphenhydramine theoclate, Diphenhydramine 8-chlorotheophyllinate

Classification

Chemical: Medicine
Psychoactive: Deliriant
Psychoactive: Depressant
Tag: Antihistamine
Tag: Common
Tag: Ethanolamine derivative
Tag: Sedative

Effects

Dry Mouth
Pupil Dilation
Increased Heart Rate
Difficulty Urinating
Tremors
Muscle Cramps
Paranoia
Irritability
Psychosis
Confusion
Amnesia
Delirium
Cognitive Dysphoria
Perception Of Bodily Heaviness
Auditory Distortion
Auditory Hallucination
Visual Distortion
External Hallucination

Routes of Administration

Oral

Dosage

Heavy: 600+ mg
Light: 25 – 150 mg
Common: 250-400 mg
Strong: 400-600 mg
Threshold: 25 mg

Duration

Onset: 0.5-1.5 h
Comeup: 0.75-1.5 h
Peak: 1-4 h
Offset: 2-6 h
After Effects: 2-24 h
Total Duration: 4-12 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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