Library

Миртазапин

At therapeutic doses (7.5-45mg), mirtazapine functions as a sedating antidepressant with appetite-stimulating effects. At higher doses (typically 100mg+), it produces atypical psychedelic and deliriant effects with extreme sedation but lacks introspective or recreational value. Paradoxically, lower doses (7.5mg) are more sedating than higher doses (30-45mg) due to offsetting noradrenergic effects. Not recommended for recreational use due to overwhelming sedation and lack of euphoria. Common side effects include weight gain, vivid dreams, dry mouth, and restless legs.

Миртазапин molecular structure
Миртазапин molecular structure diagram from the DrugsPRO substance library.

Also known as: Axit, Avanza, Zispin, Mirtaz, Norset, Remeron, Org 3770, Mepirzapine, Mirtazapinum, 6-Azamianserin

Classification

  • Chemical: Medicine
  • Psychoactive: Deliriant
  • Psychoactive: Depressant
  • Tag: Antidepressant
  • Tag: Pharmaceutical
  • Tag: Piperazinoazepine
  • Tag: Sedative
  • Tag: Tetracyclic antidepressant

Effects

  • Sedation
  • Dry Mouth
  • Restless Legs
  • Lightheadedness
  • Fatigue
  • Insomnia
  • Dream Potentiation
  • Anxiety Suppression
  • Motor Control Loss
  • Time Distortion
  • Emotion Suppression
  • Thought Deceleration
  • Appetite Enhancement
  • Increased Music Appreciation
  • Visual Acuity Suppression
  • Visual Drifting
  • Internal Hallucination
  • External Hallucination

Routes of Administration

Oral

Dosage

  • Threshold: 7.5–15 mg (sedative/off‑label insomnia)
  • Light: 70 - 130 mg
  • Common: 130 - 190 mg
  • Strong: 190 - 250 mg
  • Heavy: 250 mg
  • Bioavailability: 250 mg

Duration

  • Onset: 0.25-1 h
  • Peak: 1.5-3 h
  • Offset: 12-24 h
  • After Effects: 12-24 h
  • Total Duration: 12-24 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Mirtazapine - DrugsPRO vodič o supstancama

Mirtazapine: At therapeutic doses (7.5-45mg), mirtazapine functions as a sedating antidepressant with appetite-stimulating effects. At higher doses (typically 100mg+), it produces atypical psychedelic and deliriant effects with extreme sedation but lacks introspective or recreational value. Paradoxi

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