Very little peer-reviewed human data exist. Limited forensic reports indicate occasional appearance in illicit 'party pill' blends between 2013-2019. Animal receptor-binding screens show micromolar affinity for 5-HT2A/2C and moderate inhibition of serotonin uptake, suggesting a hybrid psychedelic-stimulant profile comparable to 4-bromo-2,5-dimethoxy-BZP (2C-B-BZP) but with lower potency. Users report a slow come-up, mild closed-eye visuals, warmth/euphoria, tachycardia, jaw tension and long-lasting stimulation. Nausea, vasoconstriction and headaches are common at >80 mg.
Also known as: 2c-benzylpiperazine, 2,5-dimethoxybenzyl, DMBZP
Classification
Chemical: Piperazine
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Benzylpiperazine
Tag: Hallucinogen
Tag: Research-Chemical
Effects
Stimulation
Teeth Grinding
Pupil Dilation
Nausea
Vasoconstriction
Restlessness
Euphoria
Increased Sociability
Anxiety
Wakefulness
Sociability Enhancement
Talkativeness
Visual Enhancement
Pattern Recognition Enhancement
Color Enhancement
Tactile Enhancement
Bodily Control Enhancement
Open Eye Visuals
Routes of Administration
Oral
Dosage
Threshold: 10 mg
Light: 20 – 40 mg
Common: 40 – 80 mg
Strong: 80 – 120 mg
Heavy: 120 mg +
Duration
Onset: 0.75-2 h
Comeup: 0.5-1.5 h
Peak: 3-6 h
Offset: 1.5-3 h
After Effects: 12-24 h
Total Duration: 6-10 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
1-(2,5-Dimethoxybenzyl) piperazine: Very little peer-reviewed human data exist. Limited forensic reports indicate occasional appearance in illicit 'party pill' blends between 2013-2019. Animal receptor-binding screens show micromolar affinity for 5-HT2A/2C and moderate inhibition of serotonin uptake
