5-MeO-DMT is a naturally occurring psychedelic of the tryptamine class, found in numerous plant species and in the venom of the Colorado River toad (Incilius alvarius). It has been used in South American shamanic snuff preparations for centuries and was first identified in the plant Dictyoloma incanescens. Reputed to produce among the most powerful and intense psychedelic states within its class, it is considerably more potent by weight than its close relative DMT — a confusion between the two can lead to dangerous overdoses.
Also known as: Toad, Bufo, 5-meo, Toads, Jaguar, O-methylbufotenine, Methoxybufotenin, Bufotenine methyl ether, MeODMT
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Tag: Alkaloid
Tag: Atypical Hallucinogen
Tag: Entheogen
Tag: Indole
Tag: Research-Chemical
Tag: substituted tryptamine
Effects
Physical Euphoria
Nausea
Bodily Pressures
Skin Flushing
Pupil Dilation
Temperature Regulation Suppression
Mindfulness
Conceptual Thinking
Anxiety
Time Distortion
Ego Suppression Loss And Death
Delusion
Changes In Gravity
Hallucinations
Color Shifting
Visual Drifting
Visual Acuity Enhancement And Suppression
Color Enhancement
Routes of Administration
Smoked
Dosage
Heavy: 20 mg
Light: 2 – 5 mg
Common: 5 – 10 mg
Strong: 10 – 20 mg
Threshold: 2 mg
Duration
Onset: 0-0.02 h
Comeup: 0.01-0.02 h
Peak: 0.1-0.2 h
Offset: 0.17-0.33 h
After Effects: 0.25-1 h
Insufflated
Dosage
Heavy: 20+ mg
Light: 5 – 8 mg
Common: 8 – 15 mg
Strong: 15–20 mg
Threshold: 3 – 5 mg
Duration
Onset: 0-0.2 h
Comeup: 0.02-0.08 h
Peak: 0.17-0.67 h
Offset: 0.5-1 h
After Effects: 60-180 h
Total Duration: 30-45 h
Oral
Dosage
Heavy: 30 mg
Light: 3 – 5 mg
Common: 5 – 10 mg
Strong: 8 – 15 mg
Threshold: 3 mg
Duration
Onset: 0.02-0.08 h
Sublingual
Dosage
Light: 5 – 8 mg
Common: 8 – 15 mg
Strong: 15 mg
Threshold: 5 mg
Duration
Onset: 0.17-0.25 h
Inhaled
Dosage
Heavy: 15 mg
Light: 2 – 5 mg
Common: 5 – 10 mg
Strong: 10 – 15 mg
Threshold: 2 mg
Duration
Onset: 0.02 h
Vaporized
Dosage
Heavy: 15+ mg
Light: 2–5 mg
Common: 5–10 mg
Strong: 10–15 mg
Threshold: 1–2 mg
Duration
Onset: 0.17-1 h
Peak: 3-10 h
Offset: 10-20 h
After Effects: 60-120 h
Total Duration: 5-20 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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5-MeO-DMT - DrugsPRO substansguide
5-MeO-DMT: 5-MeO-DMT is a naturally occurring psychedelic of the tryptamine class, found in numerous plant species and in the venom of the Colorado River toad (Incilius alvarius). It has been used in South American shamanic snuff preparations for centuries and was first identified in the plant Dicty
