Oral bioavailability is relatively low; commercial Gamalate B6 contains only 37.5 mg GABOB per tablet (standard therapeutic dose: 225 mg/day via 6 tablets). Recreational users resort to bulk powder or rectal administration. Weak potency and high inter-individual variability reported; one Bluelight user found 1 g rectally essentially without effect. Racemic mixtures display stereoselectivity: (R)-GABOB shows moderate GABA-B agonism, while (S)-GABOB is both a partial GABA-B agonist and full GABA-A agonist, making it twice as potent as an anticonvulsant. Standard harm reduction: titrate with 300 mg or less initially, avoid mixing with depressants, and store powder in desiccated containers as it is hygroscopic.
GABOB molecular structure diagram from the DrugsPRO substance library.
Also known as: Buxamine, Buxamina, Β-hydroxy-gaba, 3-hydroxy-gaba
Classification
Chemical: Medicine
Psychoactive: Depressant
Psychoactive: Nootropic
Tag: Amino acid derivative
Tag: Anticonvulsant
Tag: GABA analogue
Tag: GABAergic
Tag: Research-Chemical
Tag: Sedative
Effects
Anxiolysis
Muscle Relaxation
Sedation
Sleep Enhancement
Motor Impairment
Stimulation
Cognitive Enhancement
Reduced Anxiety
Anxiety Suppression
Focus Enhancement
Motivation Enhancement
Memory Enhancement
Appetite Enhancement
Dulled Perception
Disinhibition
Open Eye Visuals
Dehydration
Increased Libido
Routes of Administration
Oral
Dosage
Threshold: 100 mg
Light: 100-300 mg
Common: 300-800 mg
Strong: 800-1500 mg
Heavy: 1500 mg
Duration
Onset: 0.33-1 h
Peak: 1-2 h
Offset: 1-2 h
After Effects: 1-4 h
Rectal
Dosage
Threshold: 250 mg
Light: 250-600 mg
Common: 600-1200 mg
Strong: 1200-2000 mg
Heavy: 2000 mg
Duration
Onset: 0.17-0.5 h
Peak: 1-2 h
Offset: 1-2 h
After Effects: 1-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
Get the full DrugsPRO experience
Open the interactive DrugsPRO app for search, saved items, interactions, and deeper harm reduction tools.
Get the PRO test kit. The simple, quick and reliable drug checking test kit. Visit https://protestkit.eu
GABOB - DrugsPRO substansguide
GABOB: Oral bioavailability is relatively low; commercial Gamalate B6 contains only 37.5 mg GABOB per tablet (standard therapeutic dose: 225 mg/day via 6 tablets). Recreational users resort to bulk powder or rectal administration. Weak potency and high inter-individual variability reported; one Blue
