NEP is a substituted cathinone that produces stimulating, euphoric, and mildly entactogenic effects. It first appeared on the research chemical market in 2016 as a contemporary designer drug. Structurally related to pentedrone, it differs by an additional ethyl group on the terminal nitrogen, reportedly making it roughly three times as potent. NEP is also closely related to N-ethylhexedrone and is noted for its relatively short duration of action.
NEP molecular structure diagram from the DrugsPRO substance library.
Also known as: Α-eapp, Ethyl-pentedrone, N-ethylpentedrone, N-ethylnorpentedrone, Α-ethylaminopentiophenone, N-Ethylpentedron, N-Ethylpentedron hydrochloride, N-Ethylpentedron-Hydrochlorid, Ethylpentedron
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Empathogen
Tag: Research-Chemical
Tag: Tentative
Effects
Increased Heart Rate
Increased Blood Pressure
Vasoconstriction
Pupil Dilation
Stimulation
Physical Euphoria
Compulsive Redosing
Euphoria
Anxiety
Paranoia
Empathy Enhancement
Wakefulness
Increased Libido
Visual Acuity Suppression
Tactile Enhancement
Light Sensitivity
Color Enhancement
Dehydration
Routes of Administration
Oral
Dosage
Heavy: 60 mg+
Light: 10 – 20 mg
Common: 20 – 40 mg
Strong: 40 – 60 mg
Threshold: ~5–10 mg
Duration
Onset: 0.17-0.33 h
After Effects: 0.5-3 h
Peak: 1-2 h
Offset: 2-4 h
Total Duration: 3-6 h
Insufflated
Dosage
Heavy: 60+ mg
Light: 10 – 20 mg
Common: 20 – 40 mg
Strong: 40 – 60 mg
Threshold: 10 mg
Duration
Onset: 0.083-0.25 h
Comeup: 0.1-0.2 h
Peak: 0.5-1.5 h
Offset: 0.5-1.5 h
After Effects: 0.5-2 h
Total Duration: 2-4 h
Smoked
Dosage
Heavy: 50 mg
Light: 5 – 15 mg
Common: 15 – 30 mg
Strong: 30 – 50 mg
Threshold: 5 mg
Duration
Onset: 0.08 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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NEP - DrugsPRO substansguide
NEP: NEP is a substituted cathinone that produces stimulating, euphoric, and mildly entactogenic effects. It first appeared on the research chemical market in 2016 as a contemporary designer drug. Structurally related to pentedrone, it differs by an additional ethyl group on the terminal nitrogen, r
