Atropine is a naturally occurring tropane alkaloid found in Atropa belladonna and related nightshades. Medically it is employed to treat bradycardia, organophosphate poisoning, and to induce mydriasis. Recreational use is strongly discouraged: its psychoactive profile is characterised by true delirium, intense peripheral anticholinergic burden, and profound amnesia. The effective dose range for central effects lies dangerously close to the toxic and potentially lethal range; fatalities have occurred at doses only modestly above those that cause hallucinations. Individual sensitivity varies widely and children are especially vulnerable.
Atropin molecular structure diagram from the DrugsPRO substance library.
Also known as: Atropin, Atropina, Atropinum, Dl-hyoscyamine, Dl-tropyltropate, Tropine tropate
Classification
Chemical: Tropane
Psychoactive: Deliriant
Tag: Alkaloid
Tag: Hallucinogen
Tag: Tropane-alkaloid
Effects
Extreme Dry Mouth And Skin
Dilated Pupils And Blurred Vision
Tachycardia And Palpitations
Flushing And Hyperthermia
Urinary Retention And Constipation
Restlessness Alternating With Sedation
Profound Confusion And Disorientation
Retrograde And Anterograde Amnesia
Paranoia Or Aggressive Behaviour
Dizziness
Agitation
Confusion
Photophobia
Open Eye Visuals
Color Enhancement
Visual Distortion
Drifting
Visual Acuity Suppression
Routes of Administration
Oral
Dosage
Threshold: 0.3 mg
Light: 0.5 – 1 mg
Common: 2 – 5 mg
Strong: 6 – 10 mg
Heavy: 10+ mg (often toxic)
Duration
Onset: 0.5-1 h
Comeup: 1-2 h
Peak: 1-3 h
Offset: 4-8 h
After Effects: 24-72 h
Total Duration: 6-12 h
Intravenous
Dosage
Threshold: 0.2 mg (therapeutic)
Light: 0.3 – 0.6 mg
Common: 0.6 – 1 mg
Strong: 1 – 2 mg
Heavy: 2+ mg (poisoning risk)
Duration
Onset: 0.02-0.07 h
Comeup: 0.08-0.25 h
Peak: 0.25-0.5 h
Offset: 4-8 h
After Effects: 24-72 h
Total Duration: 4-8 h
Ophthalmic
Dosage
Heavy: Any non‑prescribed or ingested use = unsafe %
Light: 0.01% %
Common: 0.025–0.05% (clinical myopia control ranges) %
Strong: 0.5–1% (cycloplegia/penalization; high adverse-effect burden) %
Threshold: 0.005–0.01% (low-dose myopia control research) %
Duration
Onset: 0.5-1 h
Peak: 0.04-0.125 h
Offset: 1-3 h
After Effects: 3-20 h
Total Duration: 1-14 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Atropine - DrugsPRO madde rehberi
Atropine: Atropine is a naturally occurring tropane alkaloid found in Atropa belladonna and related nightshades. Medically it is employed to treat bradycardia, organophosphate poisoning, and to induce mydriasis. Recreational use is strongly discouraged: its psychoactive profile is characterised by t
