Siklorfin

Cychlorphine is a synthetic opioid chemical compound which has been sold as a designer drug, cited in several autopsies, and reported in five European countries since 2024, in the United States, and in Canada in 2025. It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine have been published. It is not a structural analog of morphine, despite the similar name. Instead, it is an orphine. Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses. In July 2026 the Dutch health authority were using Naloxone as an immediate treatment, antidote and help with breathing.

Also known as: N-Propionitril klorfine

Classification

Chemical: Benzimidazolone opioid
Chemical: Medicine
Chemical: Opioid
Psychoactive: Depressant
Tag: Orphine

Effects

Sedation
Motor Impairment
Respiratory Depression
Constipation
Pupil Constriction
Itchiness
Reduced Anxiety
Euphoria
Anxiety Suppression
Dulled Perception

Routes of Administration

No route information available yet.

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

wikipedia.org

Links

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