Fentanyl is a synthetic opioid of the anilidopiperidine class first synthesized by Paul Janssen in 1960 and approved for medical use in the United States in 1968. It is approximately 80 to 100 times more potent than morphine and is used clinically for anesthesia and breakthrough cancer pain. Fentanyl is widely encountered as an adulterant in illicit drug supplies, particularly heroin, where its extreme potency has contributed to numerous accidental overdoses and fatalities.
Fentanil molecular structure diagram from the DrugsPRO substance library.
Also known as: Tnt, Fent, Fenty, Fetty, Actiq
Classification
Chemical: Anilidopiperidine
Chemical: Medicine
Chemical: Opioid
Psychoactive: Depressant
Tag: Habit-Forming
Tag: Sedative
Tag: substituted piperidine
Effects
Pain Relief
Physical Euphoria
Itchiness
Respiratory Depression
Sedation
Cough Suppression
Cognitive Euphoria
Anxiety Suppression
Compulsive Redosing
Euphoria
Feelings Of Relaxation
Changes In Focus
Decreased Libido
Dulled Perception
Acuity Suppression
Appetite Suppression
Orgasm Suppression
Routes of Administration
Insufflated
Dosage
Heavy: 75 ug
Light: 5 – 25 µg
Common: 25 – 50 µg
Strong: 50 – 75 µg
Threshold: 5 ug
Duration
Onset: 0.2-0.5 h
Sublingual
Dosage
Heavy: 75 ug
Light: 5 – 25 µg
Common: 25 – 50 µg
Strong: 50 – 75 µg
Threshold: 5 ug
Duration
Onset: 0.25-0.5 h
Transdermal
Dosage
Heavy: 100+ mcg/hr
Light: 12-25 mcg/hr
Common: 25-50 mcg/hr
Strong: 50-100 mcg/hr
Threshold: 12 mcg/hr
Duration
Onset: 2-4 h
Oral
Dosage
Heavy: 200+ µg
Light: 0.025-0.05 mg (25-50 µg)
Common: 0.05-0.1 mg (50-100 µg)
Strong: 0.1-0.2 mg (100-200 µg)
Threshold: 0.01 mg (10 µg)
Duration
No data available for this section yet.
Intravenous
Dosage
Heavy: 100+ µg
Light: 0.01-0.025 mg (10-25 µg)
Common: 0.025-0.05 mg (25-50 µg)
Strong: 0.05-0.1 mg (50-100 µg)
Threshold: 0.005 mg (5 µg)
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Fentanyl - DrugsPRO madde rehberi
Fentanyl: Fentanyl is a synthetic opioid of the anilidopiperidine class first synthesized by Paul Janssen in 1960 and approved for medical use in the United States in 1968. It is approximately 80 to 100 times more potent than morphine and is used clinically for anesthesia and breakthrough cancer pai
