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Gaboxadol

Gaboxadol (THIP) is a direct-acting GABA-A receptor agonist developed by Lundbeck and Merck as an experimental sleep aid. Clinical trials were discontinued in 2007 due to narrow therapeutic index and psychiatric side effects at effective doses. Unlike benzodiazepines, it acts as an orthosteric agonist at the GABA binding site with preferential activity at extrasynaptic δ subunit-containing receptors. At low doses produces sedation and sleep enhancement; at higher doses produces distinctive hallucinogenic and deliriant effects. Not approved for medical use.

Gaboxadol molecular structure
Gaboxadol molecular structure diagram from the DrugsPRO substance library.

Also known as: Thip, Ov101, Mk-0928, Lu-2-030, Lu-02-030

Classification

  • Chemical: Medicine
  • Psychoactive: Deliriant
  • Psychoactive: Depressant
  • Tag: 3-Hydroxyisoxazole
  • Tag: Atypical Hallucinogen
  • Tag: GABAergic
  • Tag: Hallucinogen
  • Tag: Oneirogen
  • Tag: Research-Chemical
  • Tag: Sedative

Effects

  • Sedation
  • Sleepiness
  • Muscle Relaxation
  • Anxiolysis
  • Pain Relief
  • Nausea
  • Cognitive Euphoria
  • Dream Potentiation
  • Perspective Distortion
  • Memory Suppression
  • Consciousness Disconnection
  • Empathy Enhancement
  • Auditory Hallucination
  • External Hallucination
  • Internal Hallucination
  • Visual Distortion
  • Color Shifting
  • Increased Music Appreciation

Routes of Administration

Oral

Dosage

  • Threshold: 5 mg
  • Light: 5-10 mg
  • Common: 10-20 mg
  • Strong: 20-30 mg
  • Heavy: 30+ mg

Duration

  • Onset: 0.25-1 h
  • Comeup: 0.5-1 h
  • Peak: 1-2 h
  • Offset: 0-0.1 h
  • After Effects: 6-12 h
  • Total Duration: 4-8 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Gaboxadol - DrugsPRO madde rehberi

Gaboxadol: Gaboxadol (THIP) is a direct-acting GABA-A receptor agonist developed by Lundbeck and Merck as an experimental sleep aid. Clinical trials were discontinued in 2007 due to narrow therapeutic index and psychiatric side effects at effective doses. Unlike benzodiazepines, it acts as an orthos

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