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İzotonitazen

Isotonitazene (CAS 14188-81-9) was first characterized in illicit markets in 2019 and scheduled by the U.S. DEA in 2020. In vitro it shows sub-nanomolar MOR efficacy and produces more prolonged respiratory depression than equipotent fentanyl. Community users warn that Narcan may need repeat dosing. Powder is often tan-brown, poorly water-soluble; volumetric dosing in high-proof ethanol:saline (1 mg/100 mL) is recommended.

İzotonitazen molecular structure
İzotonitazen molecular structure diagram from the DrugsPRO substance library.

Also known as: Iso, Toni, Nitazene

Classification

  • Chemical: 2-Benzylbenzimidazole opioid
  • Chemical: Opioid
  • Psychoactive: Depressant
  • Tag: Benzimidazole
  • Tag: Nitazene
  • Tag: Research-Chemical

Effects

  • Analgesia
  • Itching
  • Respiratory Depression
  • Sedation
  • Miosis
  • Nausea
  • Intense Opioid Euphoria
  • Severe Dysphoria
  • Euphoria
  • Sadness
  • Withdrawal
  • Anxiety Suppression
  • Dulled Perception
  • Internal Hallucination
  • Size Distortion
  • Warmth
  • Warm Flush
  • Appetite Suppression

Routes of Administration

Insufflated

Dosage

  • Threshold: 20-40 ug
  • Light: 40-80 ug
  • Common: 80-150 ug
  • Strong: 150-300 ug
  • Heavy: 300+ ug

Duration

  • Onset: 0.03-0.08 h
  • Peak: 0.5-2 h
  • Offset: 2-3 h
  • After Effects: 12 h

Oral / Sublingual

Dosage

  • Threshold: 100 ug
  • Light: 100-250 ug
  • Common: 250-500 ug
  • Strong: 500-1000 ug
  • Heavy: 1 mg

Duration

  • Onset: 0.25-0.5 h
  • Peak: 1-3 h
  • Offset: 3-4 h
  • After Effects: 12 h

Oral

Dosage

  • Heavy: 1000+ ug
  • Light: 100–250 ug
  • Common: 250–500 ug
  • Strong: 500–1000 ug
  • Threshold: 100 ug

Duration

No data available for this section yet.

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Isotonitazene - DrugsPRO madde rehberi

Isotonitazene: Isotonitazene (CAS 14188-81-9) was first characterized in illicit markets in 2019 and scheduled by the U.S. DEA in 2020. In vitro it shows sub-nanomolar MOR efficacy and produces more prolonged respiratory depression than equipotent fentanyl. Community users warn that Narcan may need

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