2F-NENDCK is a novel dissociative first identified in Canberra, Australia in August 2022. It is a positional isomer of FXE (3'-Fluoro-2-oxo-PCE), differing only by fluorine position. In April 2023, DrugsData.org revealed that all samples previously identified as FXE actually contained 2F-NENDCK. Most substances sold as ketamine, FXE, or MXE since 2017 may have been 2F-NENDCK. Effects last significantly longer than ketamine (4-6 hours) with reports of stronger visual distortions, minimal euphoria, greater disorientation, difficulty urinating, and next-day cognitive impairment described as feeling cloudy or foggy.
Also known as: 2-fxe, 2f-o-pce, 2'-fluoro-2-oxo-pce, CanKet, 2F-NENK, 2F‑2′‑Oxo‑PCE, Canberra ketamine, 2-fluoro NENDCK, 2-FDCNEK
Classification
Chemical: Arylcyclohexylamine
Psychoactive: Dissociative
Tag: Hallucinogen
Tag: Research-Chemical
Effects
Analgesia
Physical Disconnection
Difficulty Urinating
Nausea
Pain Relief
Incoordination
Dissociation
Cognitive Impairment
Disorientation
Motor Control Loss
Dizziness
Minimal Euphoria
Visual Distortion
Double Vision
Pattern Recognition Suppression
Tactile Suppression
Perception Of Bodily Lightness
Dehydration
Routes of Administration
Oral
Dosage
Threshold: 5-10 mg
Light: 10-25 mg
Common: 25-50 mg
Strong: 50-80 mg
Heavy: 80+ mg
Duration
Onset: 0.33-0.67 h
Comeup: 0.5-1 h
Peak: 1.5-2.5 h
Offset: 1.5-3 h
After Effects: 4-12 h
Total Duration: 2-4 h
Insufflated
Dosage
Threshold: 3-8 mg
Light: 8-20 mg
Common: 20-40 mg
Strong: 40-60 mg
Heavy: 60+ mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 1.5-2 h
Offset: 1.5-2 h
After Effects: 4-12 h
Total Duration: 1.5-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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2F-NENDCK - довідник з речовин DrugsPRO
2F-NENDCK: 2F-NENDCK is a novel dissociative first identified in Canberra, Australia in August 2022. It is a positional isomer of FXE (3'-Fluoro-2-oxo-PCE), differing only by fluorine position. In April 2023, DrugsData.org revealed that all samples previously identified as FXE actually contained 2F-
