Methoxphenidine (commonly called MXP or 2-MXP) is a long-acting dissociative of the diarylethylamine class with particularly extended duration. Oral onset can take 1-2 hours, leading inexperienced users to redose prematurely and experience severe intoxication. Doses above 150 mg have produced severe confusion, blackouts, urinary tract irritation similar to ketamine cystitis, and hospitalizations. Multiple fatalities have been reported with this compound. Large crystals are caustic to nasal tissue; oral capsules are strongly preferred.
Also known as: Mxp, 2-mxp, Methoxphenidine, Methoxyphenidine, 2-meo-diphenidine, 2-Methoxydiphenidine
Classification
Chemical: Arylcyclohexylamine
Chemical: Diarylethylamine
Psychoactive: Dissociative
Tag: Habit-Forming
Tag: Hallucinogen
Tag: Research-Chemical
Tag: Tentative
Effects
Tactile Disconnection
Physical Euphoria
Pain Relief
Clumsiness In Movement
Spontaneous Tactile Sensations
Sedation
Depersonalization
Derealization
Motor Control Loss
Cognitive Euphoria
Time Distortion
Conceptual Thinking
Visual Disconnection
Increased Music Appreciation
Perception Of Bodily Lightness
Spatial Disorientation
Internal Hallucination
Warm Vibration
Routes of Administration
Oral
Dosage
Threshold: 15-25 mg
Light: 25-50 mg
Common: 50-100 mg
Strong: 120-150 mg
Heavy: 150–200 mg
Duration
Onset: 0.5-1 h
Comeup: 0.5-1 h
Peak: 2-5 h
Offset: 2-3 h
After Effects: 6-24 h
Total Duration: 4-7 h
Insufflated
Dosage
Threshold: 5-10 mg
Light: 15-30 mg
Common: 30-70 mg
Strong: 70-100 mg
Heavy: 100 mg
Duration
Onset: 0.17-0.75 h
Comeup: 0.25-0.5 h
Peak: 2-4 h
Offset: 1-2 h
After Effects: 6-24 h
Intravenous
Dosage
Threshold: 5 mg
Light: 10-20 mg
Common: 20-40 mg
Strong: 40-60 mg
Heavy: 60+ mg
Duration
Onset: 0.03-0.1 h
Peak: 0.2-1 h
Offset: 1-2 h
After Effects: 6-12 h
Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-MXP - DrugsPRO anyag útmutató
4-MXP: Methoxphenidine (commonly called MXP or 2-MXP) is a long-acting dissociative of the diarylethylamine class with particularly extended duration. Oral onset can take 1-2 hours, leading inexperienced users to redose prematurely and experience severe intoxication. Doses above 150 mg have produced
