Library
4-PrO-DMT
A synthetic psilocin prodrug that converts to 4-HO-DMT in the body via esterase enzymes. User reports indicate classic psilocybin-like effects with potentially heavier body load (nausea, warmth) compared to 4-AcO-DMT. Mouse studies confirm 5-HT2A-mediated psychedelic effects. As supply is limited and compound is unscheduled in many regions, reagent testing and proper substance verification is essential. First identified in Sweden in July 2019.
Also known as: O-propionylpsilocin, Psilacetin propanoate ester analogue, 4-ProO-DMT, 4-Propionyloxy-DMT
Classification
- Chemical: Tryptamine
- Psychoactive: Psychedelic
- Tag: Research-Chemical
Effects
- Nausea
- Bodily Warmth
- Sedation
- Physical Comfort
- Dilated Pupils
- Stimulation
- Time Distortion
- Emotion Enhancement
- Cognitive Euphoria
- Enhanced Introspection
- Conceptual Thinking
- Confusion
- Visual Geometry
- Color Enhancement
- Pattern Recognition Enhancement
- Open Eye Visuals
- Closed Eye Visuals
- Patterning
Routes of Administration
Oral
Dosage
- Threshold: 5 mg (salt as sold; see notes)
- Light: 5–15 mg (salt as sold; see notes)
- Common: 15–30 mg (salt as sold; see notes)
- Strong: 30–45 mg (salt as sold; see notes)
- Heavy: 45+ mg (salt as sold; see notes)
Duration
- Onset: 0.17-0.67 h
- Comeup: 0.33-0.67 h
- Peak: 1-2 h
- Offset: 2-4 h
- After Effects: 0.5-3 h
- Total Duration: 4-7 h
Insufflated
Dosage
- Threshold: 3 mg (salt)
- Light: 3–10 mg (salt)
- Common: 10–20 mg (salt)
- Strong: 20–30 mg (salt)
- Heavy: 30+ mg (salt)
Duration
- Onset: 0.08-0.25 h
- Comeup: 0.17-0.33 h
- Peak: 0.75-1.5 h
- Offset: 1-2 h
- After Effects: 0.5-2 h
- Total Duration: 4-6 h
Vaporized
Dosage
- Threshold: 2 mg (freebase)
- Light: 2–6 mg (freebase)
- Common: 6–12 mg (freebase)
- Strong: 12–20 mg (freebase)
- Heavy: 20+ mg (freebase)
Duration
- Onset: 0.01-0.08 h
- Comeup: 0.03-0.08 h
- Peak: 0.25-0.75 h
- Offset: 0.5-1.5 h
- After Effects: 0.25-1 h
- Total Duration: 2.5-5 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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