Acetildenafil

Acetildenafil (a.k.a. Hongdenafil) is an unapproved research chemical often detected as an undeclared adulterant in "herbal" sexual-enhancement supplements. Pharmacologically it shows sub-micromolar PDE-5 inhibition comparable to sildenafil (IC50 ≈ 7.6 nM), with a slightly longer half-life (≈ 3–5 hours) and anecdotal reports of milder facial flushing. Because it is metabolised mainly via CYP3A4, potent inhibitors can greatly increase its plasma concentration. Users report effective erectile support at 10–40 mg; however, some counterfeit tablets contain 80–120 mg, raising the risk of priapism, headache, and hypotension.

Also known as: Hongdenafil

Classification

Chemical: Medicine
Tag: Not psychoactive
Tag: PDE-5-inhibitor
Tag: Pyrazolopyrimidinone
Tag: Research-Chemical
Tag: Supplement

Effects

Improved Ability To Achievemaintain Erection
Increased Penile Firmness
Facialupperbody Flushing
Mild Nasal Congestion
Headachepressure Behind Eyes
Dyspepsia
Warmth In Extremities
Open Eye Visuals

Routes of Administration

Oral

Dosage

Threshold: 5 mg
Light: 5 – 15 mg
Common: 15 – 40 mg
Strong: 40 – 60 mg
Heavy: 60 mg +

Duration

Onset: 0.5-1 h
Peak: 1-2 h
Offset: 3-5 h
After Effects: 0.1-0.4 h

Sublingual

Dosage

Threshold: 2 mg
Light: 3 – 10 mg
Common: 10 – 25 mg
Strong: 25 – 40 mg
Heavy: 40 mg +

Duration

Onset: 0.17-0.75 h
Peak: 1-2 h
Offset: 3-5 h
After Effects: 0.1-0.4 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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