Static Library Class
Depressant
Depressant substances in the DrugsPRO library. Browse static substance pages, summaries and related harm reduction context without JavaScript.
Substances In This Class
These static substance pages were matched from the shared DrugsPRO library dataset used for prerender and no-JS delivery.
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hydrocodone
Hydrocodone is a semi-synthetic opioid of the morphinan class, derived from codeine. First synthesized in Germany in 1920 by Carl Mannich a…
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hydromorphine
Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is a morphinan opioid used to treat mo…
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hydromorphone
Hydromorphone is a semisynthetic opioid of the morphinan class, derived as a hydrogenated ketone of morphine. First introduced to the mass…
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hydroxyzine
Hydroxyzine is a first-generation antihistamine of the diphenylmethane and piperazine classes, first developed in 1956. Primarily prescribe…
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ibogaine
Ibogaine is a naturally occurring indole alkaloid primarily derived from the root bark of Tabernanthe iboga, a plant native to Central and…
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ic26
Methiodone replaces methadone's ketone with a sulfone bioisostere, preserving μ-agonism but with variable potency reported at approximately…
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imipramine
Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depressio…
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imodium
Loperamide is an over-the-counter anti-diarrheal that normally does not cross the blood-brain barrier due to P-glycoprotein efflux. At ther…
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isobutonitazene
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isobutyryl_fentanyl
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isobutyrylffentanyl_nbenzyl_analogue
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isomethadone
Isomethadone is a synthetic opioid analgesic structurally related to methadone. It was formerly available as a pharmaceutical product but h…
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isopropylu47700
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isotonitazene
Isotonitazene (CAS 14188-81-9) was first characterized in illicit markets in 2019 and scheduled by the U.S. DEA in 2020. In vitro it shows…
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isotonitazepyne
Isotonitazepyne is approximately 1000 times more potent than morphine in vitro. Active doses are in the microgram range; volumetric dosing…
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kanna
Kanna (Sceletium tortuosum) is a succulent plant native to South Africa that has been used by indigenous Khoisan peoples for thousands of y…
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kava
Kava is a psychoactive beverage and herbal product derived from the rootstock of Piper methysticum, a tropical shrub native to the western…
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ketazolam
Benzodiazepine derivative that has most of the common benzodiazepine effects. Has been seen to have similar effectiveness when compared to…
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ketobemidone
An opioid analgesic drug that also acts as an NDMA antagonist. Found to be as potent as morphine in physical side effects, and has high pot…
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kratom
Kratom is a tropical plant (Mitragyna speciosa) native to Thailand and Southeast Asia, where its leaves have been used as a traditional med…
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