Parafluorofentanyl is an extremely potent synthetic opioid and analogue of fentanyl, originally developed by Janssen Pharmaceutica during the 1960s. It is classified as a depressant with significant habit-forming potential. The substance remains rare, and relatively little is known about its pharmacological profile or safety margins. Due to its exceptional potency, it should be handled with extreme caution, and combining it with other depressants is strongly discouraged due to the heightened risk of fatal respiratory depression.
Parafluorofentanil molecular structure diagram from the DrugsPRO substance library.
Also known as: Pff, 4-fluorofentanyl, Parafluorofentanyl, p-fluorofentanyl
Classification
Chemical: Anilidopiperidine
Chemical: Opioid
Psychoactive: Depressant
Tag: Fentanyl analogue
Tag: Habit-Forming
Tag: Sedative
Tag: Tentative
Effects
Respiratory Depression
Itchiness
Nausea
Sedation
Motor Impairment
Constipation
Reduced Anxiety
Euphoria
Anxiety Suppression
Dizziness
Sadness
Cognitive Euphoria
Dulled Perception
Open Eye Visuals
Sound Dampening
Routes of Administration
Insufflated
Dosage
Heavy: 65 ug
Light: 10 – 25 µg
Common: 25 – 40 µg
Strong: 40 – 65 µg
Threshold: 10 ug
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Parafluorofentanyl - DrugsPRO anyag útmutató
Parafluorofentanyl: Parafluorofentanyl is an extremely potent synthetic opioid and analogue of fentanyl, originally developed by Janssen Pharmaceutica during the 1960s. It is classified as a depressant with significant habit-forming potential. The substance remains rare, and relatively little is kno