4-CBC is a halogenated cathinone that acts as a monoamine transporter substrate with EC50 values similar to 4-CMC, indicating strong dopaminergic stimulation and moderate serotonergic activity. Halogenated cathinones produce oxidative stress in cardiomyocytes; rat hepatocyte studies indicate mitochondrial dysfunction at concentrations above 100 µM. Physiological risks include tachycardia, hypertension, mydriasis, bruxism, thermoregulatory dysregulation, chest tightness, and seizures. Harm reduction practices: use a milligram-accurate scale, start with half a common dose to gauge sensitivity, limit redosing intervals to minimum 3 hours, keep total session usage under 250 mg, maintain hydration with 250 ml isotonic drinks per hour, and take minimum 2-week breaks between sessions. Reagent tests produce bright yellow color with Marquis reagent similar to 4-CMC; confirm identity via GC-MS or HPLC when possible.
Also known as: Para-Chloro-buphedrone, 4-chloro-buphedrone, 4-chloro-α-methylamino-butyrophenone, 4-chloro-butyrophenone cathinone
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Empathogen
Tag: Habit-Forming
Tag: Research-Chemical
Effects
Stimulation
Teeth Grinding
Physical Euphoria
Vasoconstriction
Increased Perspiration
Increased Heart Rate
Euphoria
Sociability Enhancement
Empathy Enhancement
Focus Enhancement
Compulsive Redosing
Anxiety
Tactile Enhancement
Music Enhancement
Increased Libido
Disinhibition
Color Enhancement
Visual Acuity Suppression
Routes of Administration
Oral
Dosage
Threshold: 15-20 mg
Light: 40-70 mg
Common: 70-110 mg
Strong: 110-140 mg
Heavy: 140+ mg
Duration
Onset: 0.33-1 h
Comeup: 0.5-1 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 2-8 h
Total Duration: 2-4 h
Insufflated
Dosage
Threshold: 5-10 mg
Light: 30-50 mg
Common: 50-80 mg
Strong: 80-100 mg
Heavy: 110+ mg
Duration
Onset: 0.08-0.33 h
Comeup: 0.25-0.5 h
Peak: 0.25-1 h
Offset: 0.5-1.5 h
After Effects: 2-8 h
Total Duration: 1-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-CBC: 4-CBC is a halogenated cathinone that acts as a monoamine transporter substrate with EC50 values similar to 4-CMC, indicating strong dopaminergic stimulation and moderate serotonergic activity. Halogenated cathinones produce oxidative stress in cardiomyocytes; rat hepatocyte studies indicate
