Library
5-MAPDB
5-MAPDB is a dihydrobenzofuran entactogen first characterized by Monte et al. (1993) and pharmacologically profiled by Rickli et al. (2015). It acts as a relatively selective serotonin releaser (SERT IC50 ≈1.2 μM) with minimal dopamine transporter activity (DAT IC50 ≈77 μM), giving it a highly serotonergic profile more selective than MDMA. Human experience reports are limited and contradictory, with some users describing subdued, sedating effects and others reporting MDMA-like empathy and euphoria.
Also known as: 5-MAPDB: 1-(2,3-dihydrobenzofuran-5-yl)-N-methylpropan-2-amine)
Classification
- Chemical: Benzofuran
- Chemical: Phenethylamine
- Psychoactive: Entactogen
- Psychoactive: Psychedelic
- Psychoactive: Stimulant
- Tag: Empathogen
- Tag: Research-Chemical
Effects
- Stimulation
- Pupil Dilation
- Bruxism
- Jaw Clenching
- Sweating
- Difficulty Urinating
- Euphoria
- Empathy
- Emotional Openness
- Increased Sociability
- Enhanced Music Appreciation
- Nextday Lethargy Or Low Mood
- Enhanced Tactile Sensation
- Mild Visual Enhancement
- Increased Sexuality
- Visual And Audiotory Hallucinations Itchiness
- Light Sensitivity
- Color Enhancement
Routes of Administration
Oral
Dosage
- Threshold: 20 mg
- Light: 40-70 mg
- Common: 70-110 mg
- Strong: 120-150 mg
- Heavy: 150 mg
Duration
- Onset: 0.75-1.17 h
- Comeup: 0.5-1 h
- Peak: 2-4 h
- Offset: 1-2 h
- After Effects: 2-4 h
Insufflated
Dosage
- Threshold: 5 mg
- Light: 15-25 mg
- Common: 25-40 mg
- Strong: 40-60 mg
- Heavy: 60 mg
Duration
- Onset: 0.08-0.25 h
- Comeup: 0.25-0.5 h
- Peak: 2-4 h
- Offset: 1-2 h
- After Effects: 2-4 h
Rectal
Dosage
- Threshold: 15 mg
- Light: 35-60 mg
- Common: 60-90 mg
- Strong: 90-120 mg
- Heavy: 120 mg
Duration
- Onset: 0.08-0.25 h
- Comeup: 0.25-0.5 h
- Peak: 2-4 h
- Offset: 1-2 h
- After Effects: 2-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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