Library
AKB-57
1. Potency varies widely between batches; always allergy-test with a tiny match-head amount (<0.5 mg).
2. AKB-57 is active in the low-milligram range; weighing with a 0.001 g scale or volumetric dosing in PG/VG is essential.
3. Severe adverse events reported with other indazole carboxylate/carboxamide SCRAs include seizures, acute kidney injury and psychosis; similar risks should be presumed for AKB-57.
4. AKB-57 contains an ester linkage (unlike the amide in AKB48), leading to rapid ester hydrolysis as the primary metabolic pathway.
Also known as: Apinac, adamantan-1-yl 1-pentyl-1H-indazole-3-carboxylate
Classification
- Chemical: Cannabinoid
- Chemical: Synthetic cannabinoid
- Psychoactive: Depressant
- Tag: Habit-Forming
- Tag: Hallucinogen
- Tag: Indazolecarboxylate
- Tag: Research-Chemical
Effects
- Potent Mental Sedation
- Tachycardia Then Bradycardia
- Dry Mouth
- Nauseavomiting
- Motor Incoordination
- Red Eyes
- Rapid Intoxication
- Time Distortion
- Shortterm Memory Suppression
- Paranoiaanxietypanic
- Afterglow Dysphoria Or Irritability
- Time Dilation
- Closedeye Imagery At Higher Doses
- Dulled Perception
- Internal Hallucination
- External Hallucination
- Auditory Hallucination
- Drifting
Routes of Administration
Smoked
Dosage
- Threshold: <0.5 mg
- Light: 0.5 – 1.5 mg
- Common: 1.5 – 3 mg
- Strong: 3 – 5 mg
- Heavy: >5 mg
Duration
- Onset: 0.25-1.5 h
- Peak: 0.08-0.5 h
- Offset: 0.5-1.5 h
- After Effects: 1.5-6 h
- Total Duration: 1-2 h
Oral
Dosage
- Threshold: 0.5 mg
- Light: 1 – 2 mg
- Common: 2 – 4 mg
- Strong: 4 – 6 mg
- Heavy: >6 mg
Duration
- Onset: 0.5-1.5 h
- Peak: 1-2 h
- Offset: 0.5-1.5 h
- After Effects: 4-24 h
- Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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