Alpha-PiHP is a potent synthetic cathinone and positional isomer of alpha-PHP, with significantly higher potency than cocaine and methamphetamine as a dopamine transporter inhibitor. It typically appears as white to off-white powder and is consumed orally, insufflated, or vaporized. The substance has been linked to fatal intoxications and severe adverse effects including cardiac complications, psychosis, and seizures. Users commonly report extremely unpleasant body load at higher doses, severe paranoia, and overwhelming compulsion to redose. Harm reduction practices and accurate dosing are critical due to the rapid onset and high overdose risk, especially with vaporization.
Also known as: Pihp, Funky, 4-me-pvp, Alpha-phip, Α‑pyrrolidinoisohexanophenone, 4-methyl-1-phenyl-2-pyrrolidin-1-yl-pentan-1-one
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Empathogen
Tag: Habit-Forming
Tag: Pyrrolidine
Tag: Pyrrolidinophenone
Tag: Research-Chemical
Tag: Synthetic cathinone
Tag: Tentative
Effects
Stimulation
Increased Heart Rate
Increased Blood Pressure
Vasoconstriction
Teeth Grinding
Mouth Numbing
Euphoria
Thought Acceleration
Ego Inflation
Focus Enhancement
Anxiety
Paranoia
Disinhibition
Tactile Enhancement
Spontaneous Physical Sensations
Vibrating Vision
Appetite Suppression
Dehydration
Routes of Administration
Oral
Dosage
Threshold: 3-5mg mg
Light: 5-15mg mg
Common: 15-30mg mg
Strong: 30-50mg mg
Heavy: 50mg+ mg
Duration
Onset: 0.5-1 h
Peak: 1-2 h
Offset: 2-5 h
After Effects: 6-12 h
Total Duration: 2-5 h
Insufflated
Dosage
Threshold: 1-3mg mg
Light: 3-10mg mg
Common: 10-25mg mg
Strong: 25-40mg mg
Heavy: 40mg+ mg
Duration
Onset: 0.016-0.033 h
Peak: 0.17-1 h
Offset: 2-4 h
After Effects: 6-12 h
Total Duration: 2-4 h
Vaporized
Dosage
Threshold: 1-2mg mg
Light: 2-10mg mg
Common: 10-20mg mg
Strong: 20-30mg mg
Heavy: 30mg+ mg
Duration
Onset: 0.016-0.033 h
Peak: 0.25-0.5 h
Offset: 1-3 h
After Effects: 6-12 h
Total Duration: 1-3 h
Vapourized
Dosage
Common: 10-20 mg
Light: 2-10 mg
Strong: 20-30 mg
Threshold: 1-2 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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alpha-PiHP: Alpha-PiHP is a potent synthetic cathinone and positional isomer of alpha-PHP, with significantly higher potency than cocaine and methamphetamine as a dopamine transporter inhibitor. It typically appears as white to off-white powder and is consumed orally, insufflated, or vaporized. The
