MXM (3-MeO-2'-Oxo-PCM) is the N-methyl homologue of methoxetamine; replacing the ethyl with a methyl lowers potency roughly 2- to 3-fold but shortens the high to about three hours. Forum experiments suggest oral administration is far more efficient than insufflation, likely due to low nasal absorption; 50-75 mg oral produces warm, serene dissociation and mild empathogenic warmth, while the same amount intranasally may do little. Users describe a 'ketamine-lite' float with MXE-style emotional openness, but with faster tolerance and heavier compulsion to redose. Pharmacological screens (rat brain synaptosome & PDSP panels) show high-micromolar NMDA antagonism and mid-micromolar SERT inhibition, with negligible μ-opioid activity. Because bladder and renal fibrosis seen with chronic MXE are thought to be metabolite-linked, MXM's safety profile is unknown—urotoxicity precautions (hydration, 2-week breaks) are advised.
MXM molecular structure diagram from the DrugsPRO substance library.
Also known as: Mmxe, Methoxmetamine, 3-meo-2'-oxo-pcm, Methoxymetamine, E-Methoxetamine, E-MXE, Metoxmetamine
Classification
Chemical: Arylcyclohexylamine
Psychoactive: Dissociative
Tag: Habit-Forming
Tag: Hallucinogen
Tag: Research-Chemical
Effects
Physical Disconnection
Incoordination
Impaired Balance
Nausea
Stomach Discomfort
Physical Discomfort
Cognitive Euphoria
Depersonalization
Derealization
Time Distortion
Motor Control Loss
Anxiety
Increased Music Appreciation
Tactile Enhancement
Closed Eye Visuals
Open Eye Visuals
Tactile Suppression
Double Vision
Routes of Administration
Oral / Sublingual
Dosage
Threshold: 15 mg
Light: 15-40 mg
Common: 40-90 mg
Strong: 90-150 mg
Heavy: 150 mg
Duration
Onset: 0.5-0.75 h
Comeup: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 1-12 h
Insufflated
Dosage
Threshold: 20 mg
Light: 20-60 mg
Common: 60-120 mg
Strong: 120-180 mg
Heavy: 180 mg+
Duration
Onset: 0.08-0.25 h
Comeup: 0.17-0.33 h
Peak: 0.5-1.5 h
Offset: 1-1.5 h
After Effects: 0.5-8 h
Total Duration: 1.5-3 h
Intramuscular
Dosage
Threshold: 5 mg
Light: 5-15 mg
Common: 15-35 mg
Strong: 35-60 mg
Heavy: 60 mg+
Duration
Onset: 0.03-0.08 h
Comeup: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 1-1.5 h
After Effects: 0.5-8 h
Total Duration: 2-3 h
Rectal
Dosage
Threshold: 10 mg
Light: 10-30 mg
Common: 30-70 mg
Strong: 70-120 mg
Heavy: 120 mg+
Duration
Onset: 0.17-0.33 h
Comeup: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 1-1.5 h
After Effects: 0.5-8 h
Total Duration: 2-3.5 h
Oral
Dosage
Common: 40-60 mg
Light: 20-40 mg
Strong: 60-100 mg
Threshold: 10-20 mg
Heavy: 150 mg+
Duration
Onset: 0.5-1 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 1-12 h
Total Duration: 2-4 h
Sublingual
Dosage
Heavy: 100 mg+
Light: 10–25 mg
Common: 25–60 mg
Strong: 60–100 mg
Threshold: 5–10 mg
Duration
Onset: 0.33-0.75 h
Peak: 0.5-1.3 h
Offset: 1-2 h
After Effects: 1-12 h
Total Duration: 2-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
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MXM: MXM (3-MeO-2'-Oxo-PCM) is the N-methyl homologue of methoxetamine; replacing the ethyl with a methyl lowers potency roughly 2- to 3-fold but shortens the high to about three hours. Forum experiments suggest oral administration is far more efficient than insufflation, likely due to low nasal abs
