4-Hydroxy-N,N-dimethyltryptamine (also known as 4-HO-DMT, 4-OH-DMT, and psilocin) is a naturally-occurring psychedelic substance of the tryptamine class. Psilocin is the primary psychoactive constituent in certain species of mushrooms, and as a closely related structural analog of the powerful visionary entheogen DMT (also known as N,N-dimethyltryptamine).
Psilocina molecular structure diagram from the DrugsPRO substance library.
Also known as: 4-ho-dmt, 4-oh-dmt, Psilocine, Psilotsin
Classification
Chemical: Tryptamine
Psychoactive: Entactogen
Psychoactive: Psychedelic
Tag: Empathogen
Tag: Plant-based
Tag: Research-Chemical
Tag: substituted tryptamine
Tag: Tentative
Effects
Dilated Pupils
Pupil Dilation
Stimulation
Nausea
Restlessness
Spontaneous Bodily Sensations
Introspection
Memory Suppression
Confusion
Novelty Enhancement
Time Distortion
Euphoria
Visual Distortions
Color Enhancement
Drifting
Tracers
Auditory Distortion
Color Shifting
Routes of Administration
Insufflated
Dosage
Common: 5-10 mg
Light: 2.5-5 mg
Strong: 10-15 mg
Duration
No data available for this section yet.
Oral
Dosage
Common: 10-15 mg
Light: 5-10 mg
Strong: 15-25 mg
Threshold: 5 mg
Heavy: 40 mg
Duration
Onset: 0.3-0.8 h
Comeup: 1.5-3 h
Peak: 2-3 h
Offset: 1.5-2 h
After Effects: 4-24 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Psilocin - Guida alle sostanze DrugsPRO
Psilocin: 4-Hydroxy-N,N-dimethyltryptamine (also known as 4-HO-DMT, 4-OH-DMT, and psilocin) is a naturally-occurring psychedelic substance of the tryptamine class. Psilocin is the primary psychoactive constituent in certain species of mushrooms, and as a closely related structural analog of the powe