Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the parent compound, while the resulting diazepam exhibits its typical 20-40 hour half-life. Community users exploit the powder's hygroscopic nature to prepare aqueous or PEG/ethanol solutions for oral dropper dosing but note variable potency (approximately 0.7-1.0x diazepam by mass) and sticky handling issues. Subjective reports describe a flat diazepam-like sedation with strong muscle relaxation yet reduced euphoria unless 50-75 mg or higher doses are taken. High doses may reveal nonlinear conversion kinetics.
Avizafone molecular structure diagram from the DrugsPRO substance library.
Also known as: Pro-diazepam, RO 03-7355, Avizafone dihydrochloride
Classification
Chemical: Benzodiazepine
Psychoactive: Depressant
Tag: Anxiolytic
Tag: GABAergic
Tag: Research-Chemical
Tag: Sedative
Effects
Muscle Relaxation
Sedation
Physical Euphoria
Motor Impairment
Anxiety Suppression
Amnesia
Motor Control Loss
Emotion Suppression
Thought Deceleration
Euphoria
Disinhibition
Dulled Perception
Routes of Administration
Oral (Solution / Capsule)
Dosage
Threshold: 5 mg
Light: 5-15 mg
Common: 15-30 mg
Strong: 30-60 mg
Heavy: 60 mg
Duration
Onset: 0.25-0.75 h
Peak: 1-2 h
Offset: 3-6 h
After Effects: 24 h
Intramuscular
Dosage
Threshold: 2.5 mg
Light: 5-10 mg
Common: 10-20 mg
Strong: 20-30 mg
Heavy: 30+ mg
Duration
Onset: 0.08-0.25 h
Peak: 0.75-2 h
Offset: 3-6 h
After Effects: 12-36 h
Total Duration: 6-18 h
Intranasal (Experimental)
Dosage
Threshold: 2 mg
Light: 2-5 mg
Common: 5-10 mg
Strong: 10-15 mg
Heavy: 15 mg
Duration
Onset: 0.03-0.13 h
Peak: 1-2 h
Offset: 3-6 h
After Effects: 24 h
Oral
Dosage
Heavy: 60+ mg
Light: 5–15 mg
Common: 15–30 mg
Strong: 30–60 mg
Threshold: 2–5 mg
Duration
Onset: 0.25-1 h
Peak: 1-2 h
Offset: 3-8 h
After Effects: 12-48 h
Total Duration: 6-24 h
Insufflated
Dosage
Heavy: 20+ mg
Light: 5–10 mg
Common: 10–15 mg
Strong: 15–20 mg
Threshold: 2–5 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Avizafone - DrugsPRO gwida tal-sustanza
Avizafone: Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the pare
