Brorfina

Brorphine is a piperidine-based opioid analgesic compound. Brorphine was originally discovered in a 2018 paper investigating functionally biased opioid compounds, with the intention of finding safer analgesics that produce less respiratory depression than typical opioids. Brorphine was originally reported to be highly biased, with an EC50 of 4.8nM for GTPγS binding and 182nM for β-arrestin recruitment, however a more recent study found no significant bias for any of the compounds tested, including brorphine. Its safety profile in any animal model has never been established.

Classification

Chemical: Benzimidazolone opioid
Chemical: Opioid
Psychoactive: Depressant
Tag: Orphine

Effects

Sedation
Motor Impairment
Respiratory Depression
Constipation
Pupil Constriction
Itchiness
Reduced Anxiety
Euphoria
Anxiety Suppression
Cognitive Euphoria
Compulsive Redosing
Withdrawal
Dulled Perception
Internal Hallucination
Size Distortion
Warmth
Warm Flush
Appetite Suppression

Routes of Administration

No route information available yet.

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

wikipedia.org

Links

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