Desomorphine is a semi-synthetic opioid of the morphinan class, first synthesized in the early 1930s and marketed by Roche under the trade name Permonid. Characterized by a fast onset, short duration, and analgesic potency roughly ten times that of morphine intravenously, its significant dependence potential led to withdrawal from clinical use. It is the psychoactive component of the crude street preparation known as krokodil, notorious for causing severe tissue necrosis at injection sites due to toxic impurities and is highly disadvised to use.
Desomorfina molecular structure diagram from the DrugsPRO substance library.
Also known as: Krok, Croc, Krokodil, Permonid, Crocodile, Dihydrodesoxymorphine D, Dihydrodeoxymorphine, Deoxydihydromorphine D, 6‑Deoxy‑7,8‑dihydromorphine
Classification
Chemical: Morphinan
Chemical: Opioid
Psychoactive: Depressant
Psychoactive: Stimulant
Tag: Sedative
Effects
Pupil Constriction
Skin Flushing
Sedation
Pain Relief
Respiratory Depression
Nausea
Euphoria
Anxiety Suppression
Sadness
Compulsive Redosing
Irritability
Cognitive Euphoria
Decreased Libido
Internal Visualizations
Light Sensitivity
Dulled Perception
Increased Music Appreciation
Internal Hallucination
Routes of Administration
Oral
Dosage
Heavy: 30+ mg
Light: 10 – 15 mg
Common: 15 – 20 mg
Strong: 20 – 30 mg
Threshold: < 10 mg
Duration
Onset: 0.25-1.5 h
Peak: 0.5-2 h
Offset: 1-2 h
After Effects: 2-12 h
Total Duration: 3-5 h
Intravenous
Dosage
Heavy: 3 mg +
Light: 0.5 – 1 mg
Common: 1 – 2 mg
Strong: 2 – 3 mg
Threshold: ≈ 0.25 mg
Duration
Onset: 0.01-0.03 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 2-12 h
Total Duration: 2-3 h
Insufflated
Dosage
Heavy: 8 mg +
Light: 1 – 3 mg
Common: 3 – 6 mg
Strong: 6 – 8 mg
Threshold: ≈ 1 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Desomorphine - DrugsPRO gwida tal-sustanza
Desomorphine: Desomorphine is a semi-synthetic opioid of the morphinan class, first synthesized in the early 1930s and marketed by Roche under the trade name Permonid. Characterized by a fast onset, short duration, and analgesic potency roughly ten times that of morphine intravenously, its significa
