Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contribute to reduced respiratory depression risk compared to morphine. However, pure extracts carry significantly greater overdose risk than plant material due to the natural nausea ceiling in leaf powder. Mitragynine inhibits CYP3A4, CYP2D6, and CYP1A2 enzymes, presenting substantial drug interaction potential. The alkaloid is primarily hepatically metabolized to various metabolites including 7-hydroxymitragynine, which is more potent at μ-opioid receptors.
Mitraġinina molecular structure diagram from the DrugsPRO substance library.
Also known as: 9-methoxycorynantheidine, MG, MIT, SK&F 12711, Mytraginine
Classification
Chemical: Opioid
Psychoactive: Depressant
Psychoactive: Stimulant
Tag: Alkaloid
Tag: Habit-Forming
Effects
Stimulation
Sedation
Physical Euphoria
Pain Relief
Cough Suppression
Muscle Relaxation
Cognitive Euphoria
Anxiety Suppression
Empathy Affection And Sociability Enhancement
Focus Enhancement
Motivation Enhancement
Dream Potentiation
Increased Music Appreciation
Visual Disconnection
Internal Hallucination
Appetite Suppression
Decreased Libido
Orgasm Suppression
Routes of Administration
Oral (Plant Material)
Dosage
Threshold: 0.5 g
Light: 1-2 g
Common: 2-5 g
Strong: 5-8 g
Heavy: 8 g
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 1-2 h
Offset: 2-4 h
After Effects: 24 h
Oral (Pure Mitragynine)
Dosage
Threshold: 5 mg
Light: 5-15 mg
Common: 15-30 mg
Strong: 30-50 mg
Heavy: 50 mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 1-2 h
Offset: 2-4 h
After Effects: 24 h
Oral
Dosage
Heavy: >=8 g (leaf)
Light: 1–2 g (leaf)
Common: 2–5 g (leaf)
Strong: 5–8 g (leaf)
Threshold: 0.5–1 g (leaf)
Duration
Onset: 0.25-0.75 h
Peak: 1-2 h
Offset: 2-4 h
After Effects: 6-24 h
Total Duration: 4-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Mitragynine - DrugsPRO gwida tal-sustanza
Mitragynine: Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contri
