DrugsPRO / Library / Fenilefrina

Library

Fenilefrina

Phenylephrine is classified as Peripheral sympathomimetic (alpha-1 adrenergic agonist; minimal CNS activity at therapeutic doses). It belongs to the Phenylethanolamine chemical class.

Fenilefrina molecular structure
Fenilefrina molecular structure diagram from the DrugsPRO substance library.

Also known as: Neo-Synephrine, Vazculep, Mydfrin, Sudafed PE

Classification

  • Chemical: Medicine

Effects

  • Increased Blood Pressure
  • Headache
  • Stimulation
  • Numbness
  • Pain Relief
  • Anxiety
  • Disembodiment
  • Giddiness
  • Open Eye Visuals

Routes of Administration

Oral

Dosage

  • Heavy: ≥40 mg (not recommended; poor efficacy, higher risk)
  • Light: 5–10 mg
  • Common: 10–20 mg
  • Strong: 20–30 mg (limited evidence of benefit)
  • Threshold: 5 mg

Duration

  • Onset: 0.25-0.5 h
  • Peak: 0.5-1 h
  • Offset: 1-2 h
  • After Effects: 0-0.5 h
  • Total Duration: 2-4 h

Intravenous

Dosage

  • Heavy: >200 mcg (not recommended outside specific ICU/OR protocols)
  • Light: 40–60 mcg
  • Common: 50–100 mcg
  • Strong: 100–200 mcg
  • Threshold: 25–40 mcg

Duration

  • Onset: 0.02-0.05 h
  • Peak: 0.05-0.08 h
  • Offset: 5-20 h
  • After Effects: 0 h
  • Total Duration: 0.08-0.33 h

Insufflated

Dosage

  • Heavy: Prolonged daily use >3–5 days (avoid; rebound risk) %
  • Light: 0.125–0.25% %
  • Common: 0.25–1% (short‑term use) %
  • Strong: 1% (short‑term use only) %
  • Threshold: 0.125% %

Duration

  • Onset: 0.08-0.17 h
  • Peak: 0.25-0.5 h
  • Offset: 1-3 h
  • After Effects: 0 h
  • Total Duration: 2-4 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Phenylephrine - DrugsPRO gwida tal-sustanza

Phenylephrine: Phenylephrine is classified as Peripheral sympathomimetic (alpha-1 adrenergic agonist; minimal CNS activity at therapeutic doses). It belongs to the Phenylethanolamine chemical class.

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