Diphenidine is a dissociative anesthetic of the diarylethylamine class that acts as an NMDA receptor antagonist. First synthesized in 1924, it emerged on the grey market following the 2013 UK ban on arylcyclohexylamines. Its structure closely resembles that of MK-801 (dizocilpine). High doses have been associated with bizarre somatosensory phenomena and transient anterograde amnesia. The dose-response curve is reported to be particularly steep, warranting careful attention to dosing.
Дифенидин molecular structure diagram from the DrugsPRO substance library.
Also known as: Dpd, Dnd, 1,2-dep
Classification
Chemical: Arylcyclohexylamine
Chemical: Diarylethylamine
Psychoactive: Dissociative
Tag: Habit-Forming
Tag: Hallucinogen
Tag: Research-Chemical
Tag: Tentative
Effects
Tactile Disconnection
Spontaneous Tactile Sensations
Physical Euphoria
Nausea
Increased Heart Rate
Stimulation
Consciousness Disconnection
Ego Suppression Loss And Death
Thought Deceleration
Information Processing Suppression
Time Distortion
Cognitive Euphoria
Tactile Suppression
Hallucinations
Environmental Cubism
Environmental Orbism
Scenery Slicing
Internal Hallucination
Routes of Administration
Oral
Dosage
Heavy: 110-150 mg
Light: 50 – 85 mg
Common: 85 – 110 mg
Strong: 110 – 150 mg
Threshold: 15–30 mg
Duration
Onset: 0.25-0.5 h
After Effects: 4-24 h
Peak: 1-3 h
Offset: 3-6 h
Total Duration: 2-5 h
Rectal
Dosage
Threshold: 10–15 mg
Heavy: 120+ mg
Common: 20-40 mg
Light: 10-20 mg
Strong: 80–120 mg
Duration
Onset: 0.17-0.33 h
Peak: 0.75-2.5 h
Offset: 2-6 h
After Effects: 4-24 h
Total Duration: 2-6 h
Smoked
Dosage
Heavy: 55 mg
Common: 20-40 mg
Light: {'max': 20}
Strong: 40-55 mg
Duration
Onset: 0 h
Peak: 0.5-2 h
Offset: 0.3-0.7 h
After Effects: 2-5 h
Sublingual
Dosage
Heavy: 140+ mg
Light: 25–50 mg
Common: 50–100 mg
Strong: 100–140 mg
Threshold: 15–25 mg
Duration
No data available for this section yet.
Insufflated
Dosage
Heavy: 100+ mg
Light: 10–25 mg
Common: 25–60 mg
Strong: 60–100 mg
Threshold: 5–10 mg
Duration
Onset: 0.08-0.25 h
Peak: 0.5-2 h
Offset: 2-5 h
After Effects: 4-24 h
Total Duration: 2-5 h
Vaporized
Dosage
Heavy: 50+ mg
Light: 5–15 mg
Common: 15–35 mg
Strong: 35–50 mg
Threshold: 2–5 mg
Duration
Onset: 0.02-0.08 h
Peak: 0.25-1.5 h
Offset: 1-4 h
After Effects: 4-24 h
Total Duration: 1.5-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Diphenidine - DrugsPRO vodič o supstancama
Diphenidine: Diphenidine is a dissociative anesthetic of the diarylethylamine class that acts as an NMDA receptor antagonist. First synthesized in 1924, it emerged on the grey market following the 2013 UK ban on arylcyclohexylamines. Its structure closely resembles that of MK-801 (dizocilpine). High
