Library
MK-801
Potency is in the microgram range; calibrated 0.1 mg precision scale or volumetric dosing is mandatory. Subjective duration (20-48 h) far exceeds the 2 h rat plasma half-life because of high receptor affinity and slow dissociation. Animal studies show rapid formation of Olney's lesions in the retrosplenial cortex at equivalent doses to 1 mg/kg; human relevance unknown but caution advised. Users commonly report pronounced macropsia/micropsia, spatial warping and auditory hallucinations rather than classic dissociative euphoria. Severe amnesia, insomnia and thought-disorder are typical above 100 ug.
Also known as: Dizocilpine
Classification
- Psychoactive: Dissociative
- Tag: Arylcyclohexyl-related NMDA antagonist
- Tag: Diarycycloheptene
- Tag: Habit-Forming
- Tag: Hallucinogen
- Tag: Research-Chemical
- Tag: Tentative
Effects
- Nystagmus
- Incoordination
- Impaired Balance
- Insomnia
- Profound Dissociation
- Time Dilation
- Ego Fragmentation
- Motor Control Loss
- Cognitive Impairment
- Memory Suppression
- Auditory Hallucination
- Visual Distortion
- Open Eye Visuals
- Voices
- Warping
- Size Distortion
Routes of Administration
Oral / Sublingual
Dosage
- Threshold: 25 ug
- Light: 25-50 ug
- Common: 50-100 ug
- Strong: 100-300 ug
- Heavy: 300 ug
Duration
- Onset: 0.25-1 h
- Comeup: 1-2 h
- Peak: 4-10 h
- Offset: 8-24 h
- After Effects: 24-72 h
Insufflated
Dosage
- Threshold: 25 ug
- Light: 25-50 ug
- Common: 50-80 ug
- Strong: 80-250 ug
- Heavy: 250 ug
Duration
- Onset: 0.166-0.5 h
- Comeup: 1-2 h
- Peak: 3.5-9 h
- Offset: 10-24 h
- After Effects: 24-72 h
- Total Duration: 24-48 h
Intramuscular
Dosage
- Threshold: 15 ug
- Light: 15-30 ug
- Common: 30-100 ug
- Strong: 100-250 ug
- Heavy: 250 ug
Duration
- Onset: 0.083-0.25 h
- Comeup: 0.5-1.5 h
- Peak: 4-10 h
- Offset: 10-24 h
- After Effects: 24-72 h
- Total Duration: 24-48 h
Rectal
Dosage
- Threshold: 25 ug
- Light: 25-50 ug
- Common: 50-100 ug
- Strong: 100-300 ug
- Heavy: 300 ug
Duration
- Onset: 0.25-0.75 h
- Comeup: 1-2 h
- Peak: 4-10 h
- Offset: 8-24 h
- After Effects: 24-72 h
Oral
Dosage
- Heavy: 2.0 mg+
- Light: 0.05 mg - 0.30 mg
- Common: 0.30 mg - 1.0 mg
- Strong: 1.0 mg - 2.0 mg
- Threshold: 0.05 mg
Duration
- Onset: 0.25-1 h
- Peak: 4-10 h
- Offset: 12-24 h
- After Effects: 24-72 h
- Total Duration: 24-48 h
Sublingual
Dosage
- Heavy: 2.0 mg+
- Light: 0.05 mg - 0.30 mg
- Common: 0.30 mg - 1.0 mg
- Strong: 1.0 mg - 2.0 mg
- Threshold: 0.05 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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