How to test KETAMINE?

How to test ketamine (special k): reduce risk by using a ketamine test kit to check it for adulterants. Pure ketamine usually looks white but can’t be identified by appearence. To test ketamine use reagent tests Mecke, Mandelin, Liebermann and Froehde in single-use or multiple-use test kits. Reagent tests are simple chemicals that indicate presence of a substance by reacting with different color change to different substances.  To test you need just 1 drop of a reagent and a small sample, about this big -> To detect all ingredients and estimate potency it’s required to use an additional ketamine purity test kitTo detect fentanyl or test for fentanyl analogs use the fentanyl test strips.

Reagents presumptively indicate PRESENCE, but not PURITY or QUANTITY. Use different reagent tests to improve accuracy and to detect adulterants – 90% of adulterants will react with 1 out of 3 tests and 95% with 1 out of 5. To detect all ingredients and estimate potency it’s required to use an additional purity test kitA positive or negative test result does not indicate if the substance is safe. No substance is 100% safe.

How can I test ketamine?

Short instructions:

BEFORE using a ketamine test kit
  • it’s RECOMMENDED to record the reaction to compare later.
  • if testing a pill, crush it finely and proceed testing using the powder
Ketamine testing instructions
  • Take a (small) piece of your powder/pill, about this big -> ●.
  • Put it on a suitable testing plate, preferably a spot test plate or the bottom/underside of a ceramic mug (example). *If using single-use vials insert the sample and observe, as the reagent is already within.
  • Add one (or two) drops of Mandelin reagent test (or other supplied) on the sample and wait for the results.
  • Check reagent test results with instructions below.
  • Consider using the TLC Ketamine Purity Test Kit to double check possible adulterants and estimate potency.
AFTER using a ketamine test kit
  • OPTIONAL: Pour baking soda over a finished reaction to neutralize used reagents.
  • Wash testing surface under running water.

For full instructions scroll further down below.

VIDEO & RESULTS Watch how to test ketamine

TL;DR: Below is an image with a quick cheat sheet how to use the Ketamine Test Kit and further down you can check out more detailed guide how to test ketamine. Use the ketamine reagent test results chart to see how to use Mandelin reagentMecke, Liebermann and Froehde and what are the expected results.

All ketamine test results:

MECKE No color change
MANDELIN Orange > Brown
LIEBERMANN Light Yellow / no change
FROEHDE No color change
EHRLICH No color change
HOFMANN No color change
SIMON’S No blue color change
ROBADOPE No pink color change
SCOTT No full color change


Ketamine test did not react as expected? Watch out!
All test results are available in our instructions and the TestDrugs app.

STEP ONE How to identify ketamine?

What test kit do I need to test ketamine?


Reagents can be divided into primary and secondary. Primary reagents react with the expected substance while secondary produce a vibrant color change with an adulterant. Here are a few key notes:

  • Mandelin – primary test for ketamine, amphetamine, MDMA and more; yellow; short shelf life
  • Liebermann – primary test for most powders, secondary test for cocaine (detects levamisole)
  • Mecke – secondary test for cocaine, ketamine, mephedrone, primary test for most powders; short shelf life
  • Froehde – secondary test for ketamine and amphetamines, primary test for most powders, long shelf life

Mandelin reagent is the main test for ketamine and produces a strong orange color change which fades to brown. Liebermann reagent is the follow up primary test to confirm the presence of ketamine, although it’s reaction is faintly yellow or even not visible at all. Mecke and Froehde should not react, therefore are useful to detect any adulterants.

Ketamine test results with Mandelin reagent, Mecke, Froehde, Liebermann.

Ketamine reagent tests Mecke, Liebermann, Mandelin, Froehde

How to use the ketamine test kit?
  • Check test results with Mandelin test kit: if testing ketamine there should be an orange color change turning darker over time.
  • Never test with any reagent alone, especially Mandelin test. Mandelin reacts with an orange color change (of various intensity) to most hydrochloride salts, so plenty of research chemicals.
  • Testing with Liebermann reagent can be confusing, because it’s faint yellow color change might not be visible at all in some cases.
  • Test as small sample as possible and only try more if you are not getting a conclusive result.

STEP TWO How to test ketamine purity?

According to the EMCDDA and most common ketamine adulterants are caffeine, creatine and novel dissociatives. The latter can be detected with reagents.

Try secondary reagents. Secondary reagents produce a vibrant color change with an adulterant, but not with the expected substance.

Secondary reagent tests for ketamine:
  • Marquis reagent does not react with ketamine, but does with most powders
  • Mecke reagent does not react with ketamine, but does with most powders
  • Froehde reagent does not react with ketamine or amphetamines, but does with most powders
  • Simon’s reagent can confirm secondary amines (meth, MDMA, x-MMC, or PMMA)
  • Robadope reagent can confirm primary amines (amphetamine, MDA, 2C-x or PMA)
  • Zimmermann reagent can detect secondary (4-MMC derrivatives) and tertiary (a-PVP analogs) cathinones
How to test MDMA with reagent test Marquis, Simon's and Robadope

Expected pure ketamine reagent test results

Pure ketamine expected results: yellowish Liebermann, brown Mandelin, clear Mecke and Froehde (top).

Next choose a purity testing kit. It enables you to separate sample into different substances and estimate quantity, however still requires reagent tests to identify detected substances. To discover all adulterants and quantity pair reagents with a TLC (Thin Layer Chromatography) Purity Test Kit. Purity tests alone don’t identify substances and are best paired with 1-2 reagent tests.

TLC Purity Tests:
  • Qualitative: One spot indicates a pure substance. TLC test works by separating substances present in a sample in order to reagent test them individually.  You can also use an already confirmed sample for reference – if both compounds show up at the same height on the TLC “card” that indicates they are the same substance.
  • Semi-quantitative: TLC also helps estimate quantity (potency). The bigger the size of the detected spot, the bigger the amount of measured substance. Note that different substances need different calibrated rulers.
TLC Purity Test potency scale

TLC Purity Test potency scale

  • To estimate ketamine purity (number of ingredients and their concentration) use the Substance Purity Test Kit.
  • To precisly estimate MDMA purity use the MDMA Purity Test Kit, which in addition includes a calibrated plastic ruler.

For full TLC (Thin Layer Chromatography) instructions read our guide how to test drugs purity.

FENTANYL How to detect fentanyl?

What is fentanyl?

Fentanyl is an extremely potent and dangerous synthetic opioid, often mixed in street drugs and deadly.

BEFORE using a fentanyl test strip
  • It’s RECOMMENDED to test each and every dose. Because of extreme potency (microgram range) fentanyl is never evenly mixed in. One part of a baggie can be fentanyl free and another lethal.
How to test KETAMINE?
How to test fentanyl powder / pills / spice with a fentanyl test strip?
  • Dissolve 100 mg in at least 125 ml of water (half a cup or at least 1 mg/ml).
  • Grab a test strip and insert the white end into the liquid, no higher than the thick line.
  • Wait until liquid starts visibly moving up the test strip (up to 15 seconds).
  • Put the test strip away on a flat dry surface and read the result in 2 minutes.
  • Check test strip result: a single line confirms the presence of fentanyl, while two lines (even faint) rule it out.

Fentanyl test did not react as indicated? Watch out!
All test results are available in our instructions and the TestDrugs app.

Looking where to buy a test kit for fentanyl?

FAQ Frequently Asked Questions

Looking where to buy a kit for testing ketamine?

List of all PRO Test guides how to test drugs:

How to test 2C-B?
How to test MDA?
How to test MDMA?
How to test LSD?
How to test DMT?
How to test FENTANTYL?
How to test COCAINE?
How to test KETAMINE?
How to test MEPHEDRONE?
How to test AMPHETAMINE?
How to test HEROIN (opioids)?
How to test THC and CBD?

and how to detect cuts or other adulterants:

How to detect LEVAMISOLE?
How to detect PMA/PMMA?
How to detect FENTANYL?
How to detect NBOMes?


A positive reaction does not indicate if the substance is safe. Remember to avoid mixing with other drugs, take care of yourself and take breaks. Ketamine can be habit forming and is known to cause bladder damage in those cases, therefore regular use can be particularly dangerous. Learn more at