Drug Purity Report Week 40, 2026
This article has been translated to English.
Drug Purity Report #40/26. Welcome to “last week on drugs”, the series by PRO Test that brings you new pieces of the drugs purity puzzle. This week we focus on synthetic cannabinoids and rare, really obscure stimulants. Available lab results originate in Western Europe, but the detected patterns are likely to have a much wider reach.
Data fatigue is real, so here we come to give you the gist of what’s going on out there. For more details, photos, and other information on thousands of drugs, head out straight to the DrugsPRO app.
1. Synthetic cannabinoids are not going anywhere. Semi-synthetics such as delta8-THC and HHC, with relatively similar safety and effect profile to THC, are least of the worries. Strong cannabinoid receptors agonists such as 5F-ADB or MDMB-PINACA are being spotted as well. Despite cannabis being the most popular controlled psychoactive substance, it constitutes a relatively small part of samples tested, but that doesn’t necessarily indicate the problem is small too. Most drug checking projects only accept cannabis samples with serious reported adulteration suspicion, due to high cost of laboratory analysis, and most people who use drugs are unaware they can test their product.
2. A stimulant curiosity: bupropion and diethylpropion, pharmaceuticals and cathinone derivatives, were found in pills and powders missold as mephedrone and MDMA (Bart Simpson pills). Bupropion is normally used as an antidepressant and smoking quitting aid, and diethylpropion is a more stimulating appetite suppressant. Those findings suggests sellers are having only ever increasing problems sourcing 3-MMC and 4-MMC and are scraping the barrel, desperate to sell anything. Another detected cathinone was 4-MEC, a novel psychoactive compound not of medical origin. It’s risk profile is largely unknown, and recreational effect commonly described as less desirable than Mephedrone’s.
Scam of the Week
Samples that were not what they were sold as. Substitutions like these can be picked up with a test kit before anything is taken.
Dishonourable mentions from this week. What the lab actually found, with the date and the place it was checked.
| What was in it | Sold as | When | Where |
|---|---|---|---|
| 5F-ADB, THC | 1 October | Lausanne, Switzerland |
Last Week at a Glance
- 77 samples from 5 countries (Austria, Denmark, Slovenia, Spain and Switzerland) were included this week.
- 35 samples contained a quantified result, including 20 pills and 3 LSD samples.
- 13 samples contained more than one detected ingredient.
- No supported purity or content change was available for comparison.
What People Searched For
Below is a list of substances people are searching for in the DrugsPRO app when coming from Google, ordered by how often they were searched over the past week. Something suddenly on the rise can stand out in search interest before it shows up in lab results.
| # | Substance | Trend |
|---|---|---|
| 1 | NEP | steady |
| 2 | Ethylbromazolam | steady |
| 3 | MDPHP | steady |
| 4 | Bromonordiazepam | cooling |
| 5 | Flubrotizolam | cooling |
| 6 | 4-Pro-MET | rising |
| 7 | 4-Pro-MET | cooling |
| 8 | 1Fe-LSD | cooling |
| 9 | Methiodone | steady |
| 10 | 4-CMC | cooling |
Substances in Focus
Three substances covered in more detail this week: what they are, and how they are dosed and how long they last by route of administration. Doses and durations come from the DrugsPRO library and describe the substance itself, not any tested sample.
4-MEC
4-MEC is a substituted cathinone with stimulant and entactogen properties, structurally related to mephedrone. It has been marketed alone or blended with other cathinones under names such as “NRG-2” and has been identified as an active ingredient in counterfeit ecstasy tablets in some countries. Read more on dose.wiki
Source: erowid.org, tripsit.me
Insufflated
Dose range
Duration
Onset 0.08-0.25 hPeak 0.5-1 hOffset 1-3 h
Total: 2-4 h. After effects: 1-4 h.
Oral
Dose range
Duration
Onset 0.17-0.75 hPeak 1-2 hOffset 2-4 h
Total: 3-6 h. After effects: 2-4 h.
Intravenous
Dose range
Duration
Onset 0-0.03 hPeak 0.08-0.25 hOffset 0.5-1.5 h
Total: 1-2 h. After effects: 1-4 h.
Source: dose.wiki, tripsit.me, substance.wiki
Bupropion
Bupropion is an atypical antidepressant belonging to the substituted cathinone and phenethylamine classes. First marketed under the brand name Wellbutrin, it functions as a norepinephrine-dopamine reuptake inhibitor (NDRI) and is prescribed for major depressive disorder, seasonal affective disorder, and smoking… Read more on dose.wiki
Source: erowid.org, tripsit.me
Oral
Duration
Onset 0.25-1.5 h
After effects: 1-6 h.
Source: dose.wiki
Diethylpropion
Diethylpropion is classified as Stimulant; anorectic (sympathomimetic). It belongs to the Aminoketone; substituted cathinone; phenethylamine chemical class.
Source: substance.wiki
Oral
Dose range
Duration
Onset 0.66-1.5 hPeak 1.5-4 hOffset 4-7 h
Total: 6-8 h. After effects: 7-10 h.
Insufflated
Dose range
Source: substance.wiki
Bars are drawn to the same scale within a substance. An open-ended band such as “175+ mg” is shown reaching the end of the scale.
Purity and Content
Below, the big number in each row is the typical result for 28 September–4 October 2026: half the samples came in stronger, half weaker. The smaller one in brackets is the same thing measured over the last twelve months.
No substance had enough quantified samples for this reporting period.
Most Common Adulterants and Other Impurities
Across the last 365 days, 1,977 mixed samples contained 133 distinct additional ingredients.
| Samples | Additional ingredient | Share of substance mixtures | Most often found with |
|---|---|---|---|
| 702 | Caffeine | 84.9% of amphetamine samples · higher than last week |
Amphetamine, Heroin, MDMA |
| 281 | Unknown | 24.1% of MDMA samples · lower than last week |
MDMA, Mephedrone, 2C substances |
| 159 | Paracetamol | 81.8% of heroin samples · lower than last week |
Heroin, Cocaine, Ketamine |
| 110 | MDMA | 43.4% of ketamine samples · lower than last week |
Ketamine, 2C substances, Mephedrone |
| 110 | Procaine | 34.4% of cocaine samples · higher than last week |
Cocaine, Mephedrone, Ketamine |
| 107 | iso-LSD | 94.7% of LSD samples |
LSD |
| 106 | 4-CMC | 34.2% of mephedrone samples · lower than last week |
Mephedrone, MDMA, Ketamine |
| 99 | Ketamine | 17.4% of MDMA samples · lower than last week |
MDMA, Amphetamine, Cocaine |
| 64 | Phenacetin | 16.3% of cocaine samples · higher than last week |
Cocaine, Heroin, Ketamine |
| 59 | Levamisole | 20.1% of cocaine samples · higher than last week |
Cocaine, Ketamine |
| 57 | 2-MMC | 11.9% of mephedrone samples · lower than last week |
Mephedrone, Ketamine, MDMA |
| 44 | 4-BEC | 21.8% of mephedrone samples · higher than last week |
Mephedrone, Ketamine |
| 42 | Amphetamine | 13.2% of ketamine samples · higher than last week |
Ketamine, MDMA, Cocaine |
| 42 | Cocaine | 12.5% of ketamine samples · higher than last week |
Ketamine, Heroin, Amphetamine |
| 37 | 2C-B | 8.5% of MDMA samples · lower than last week |
MDMA, Ketamine, Amphetamine |
| 36 | 4-MMC | 7.1% of MDMA samples · higher than last week |
MDMA, Ketamine, Cocaine |
| 31 | 1-PEA | 6.6% of amphetamine samples · lower than last week |
Amphetamine, MDMA |
| 29 | DPIA | 6.3% of amphetamine samples · lower than last week |
Amphetamine |
| 26 | NEP | 7.4% of mephedrone samples · lower than last week |
Mephedrone, MDMA, Ketamine |
| 25 | d-8-Tetrahydrocannabinol | 28.4% of THC samples |
THC/cannabinoids |
Impurities Detected This Week
MDMA: Diethylpropion (1)
Amphetamine: Caffeine (2)
Ketamine: Filler (1)
2C substances: Filler (3)
LSD: iso-LSD (1)
THC/cannabinoids: 5F-MDMB-PINACA (2), d-8-Tetrahydrocannabinol (3), Free Cbd (4), Free Thc (4), MDMB-PINACA (1)
Remaining detected substances: 2-MMC (4), 4-CMC (7), 4-MEC (1), Bupropion (2), Cmc (1), Diethylpropion (1), Filler (3)
Data Sources
This report is based on drug-checking data published by: addiction-neuchatel.ch, ailaket.com, checkit.wien, contact-suchthilfe.ch, DILU, drogart.org, drogenarbeitz6.at, drugchecking.berlin, drugchecking.ch, druglab.fr, DrugsData, École des sciences criminelles (ESC), energycontrol.org, IRM Basel, knowyourstuff.nz, neutravel.net, nightlifevaud.ch, nuit-blanche.ch, Pharmazeutischen Kontrolllabor Bern, raveitsafe.ch, Reseachem GmbH, saferdancebasel.ch, SaferParty.ch, stoftest.org, tragwerk-luzern.ch, Trimbos, triptalks.at, Université Lausanne, wedinos.wales.
All of this data is available at your fingertips in the DrugsPRO app for Android, iOS, and the web.
Drug-checking results describe tested samples only and are not representative of the entire market.
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No test result can tell you a substance is safe. No substance is 100% safe.This article is published for harm reduction purposes. It does not encourage the use of psychoactive substances and does not replace medical advice.