How to test MEPHEDRONE?

How to test mephedrone (4-MMC): reduce risk by using a mephedrone test kit to check it for adulterants. Pure mephedrone usually looks white, but can’t be identified by appearence. To test mephedrone use reagent tests MarquisMecke, Liebermann, Froehde and Zimmermann in multiple-use test kits. Reagent tests are simple chemicals that indicate presence of a substance by reacting with different color change to different substances. To test you need just 1 drop of a reagent and a small sample, about this big -> To detect all ingredients and estimate potency it’s required to use an additional mephedrone purity test kitTo detect fentanyl or test for fentanyl analogs use the fentanyl test strips.

Reagents presumptively indicate PRESENCE, but not PURITY or QUANTITY. Use different reagent tests to improve accuracy and to detect adulterants – 90% of adulterants will react with 1 out of 3 tests and 95% with 1 out of 5. To detect all ingredients and estimate potency it’s required to use an additional purity test kitA positive or negative test result does not indicate if the substance is safe. No substance is 100% safe.

How can I test mephedrone?

Short instructions:

BEFORE using a 4-MMC test kit
  • it’s RECOMMENDED to record the reaction to compare later.
  • if testing a pill, crush it finely and proceed testing using the powder.
Mephedrone testing instructions
  • Take a (small) piece of your powder/pill, about this big -> ●.
  • Put it on a suitable testing plate, preferably a spot test plate or the bottom/underside of a ceramic mug (example). *If using single-use vials insert the sample and observe, as the reagent is already within.
  • Add one (or two) drops of Marquis reagent test (or other supplied) on the sample and wait for the results.
  • Check reagent test results with instructions below.
  • Consider using the TLC Mephedrone Purity Test Kit to double check possible adulterants and estimate potency.
AFTER using a mephedrone test kit
  • OPTIONAL: Pour baking soda over a finished reaction to neutralize used reagents.
  • Wash testing surface under running water.

For full instructions scroll further down below.

VIDEO & RESULTS Watch how to test mephedrone

TL;DR: Below is an image with a quick cheat sheet how to use the Mephedrone Test Kit and further down you can check out more detailed guide how to test mephedrone. Use the 4-MMC reagent test results chart to see how to use Marquis reagentMecke, Liebermann, Froehde and Simon’s and what are the expected results.

All mephedrone test results:

TEST Mephedrone (4-MMC)
MARQUIS No color change
MECKE No color change
FROEHDE No color change
EHRLICH No color change
HOFMANN No color change
SIMON’S Slow blue
ROBADOPE No pink color change
SCOTT No full color change
ZIMMERMANN Purple > Brown


Mephedrone test did not react as expected? Watch out!
All test results are available in our instructions and the TestDrugs app.

STEP ONE How to identify mephedrone?

What test kit do I need to test mephedrone (4-MMC)?


Reagents can be divided into primary and secondary. Primary reagents react with the expected substance while secondary produce a vibrant color change with an adulterant. Here are a few key notes:

  • Liebermann – primary test for most powders, also a secondary test for cocaine (detects levamisole)
  • Zimmermann – primary test for cathinones (secondary and tertiary, MMC and PVP analogs) and benzodiazepines
  • Marquis – primary test for most powders, secondary test for cocaine, ketamine, mephedrone and blotters
  • Mecke – primary test for most powders, secondary test for cocaine, ketamine, mephedrone; short shelf life
  • Froehde – secondary test for mephedrone, ketamine and amphetamines, primary test for most powders, long shelf life

Liebermann reagent is the main test for mephderone and produces an instant yellow color change with MMC, but also a few other cathinones. Zimmermann reagent is the follow up primary test to confirm the presence of a secondary cathinone (mephedrone derrivative), or tertiary (a-PVP analog). Marquis reagent, Mecke and Froehde should not react and are useful in detecting adulterants.

How to use the mephedrone test kit?
  • Check test results with the Liebermann test kit: if testing MMC there should be a yellow color change.
  • To confirm the presece of a secondary cathinone (MMC or analog) follow up with the Zimmermann test.
  • Do not use the Mandelin reagent as a primary test, it produces a lot of false positives for cathinones.
  • MMC should not react with all of the following reagent tests: Marquis, Mecke, Mandelin, Liebermann and Froehde.
  • Marquis can sometimes produce a faint yellow reaction.
  • Test as small sample as possible and only try more if you are not getting a conclusive result.

STEP TWO How to test mephedrone purity?

According to the EMCDDA and the most common mephedrone adulterants are other synthetic cathinones and caffeine.

Try secondary reagents. Secondary reagents produce a vibrant color change with an adulterant, but not with the expected substance.

Secondary reagent tests for mephedrone:
  • Marquis reagent does not react with MMC or ketamine, but does with most powders
  • Mecke reagent does not react with MMC or ketamine, but does with most powders
  • Mandelin reagent does not react strong with MMC, unlike with classic psychoactives
  • Froehde reagent does not react with MMC, ketamine or amphetamines, but does with most powders
  • Robadope reagent can confirm primary amines (MDA, 2C-x, amphetamine or PMA)
  • Simon’s reagent can confirm secondary amines (MDMA, meth, x-MMC, or PMMA)
How to test MEPHEDRONE?

Next choose a purity testing kit. It enables you to separate sample into different substances and estimate quantity, however still requires reagent tests to identify detected substances. To discover all adulterants and quantity pair reagents with a TLC (Thin Layer Chromatography) Purity Test Kit. Purity tests alone don’t identify substances and are best paired with 1-2 reagent tests.

TLC Purity Tests:
  • Qualitative: One spot indicates a pure substance. TLC test works by separating substances present in a sample in order to reagent test them individually.  You can also use an already confirmed sample for reference – if both compounds show up at the same height on the TLC “card” that indicates they are the same substance.
  • Semi-quantitative: TLC also helps estimate quantity (potency). The bigger the size of the detected spot, the bigger the amount of measured substance. Note that different substances need different calibrated rulers.
TLC Purity Test potency scale

TLC Purity Test potency scale

  • To estimate mephedrone purity (number of ingredients and their concentration) use the Substance Purity Test Kit.
  • To precisly estimate MDMA purity use the MDMA Purity Test Kit, which in addition includes a calibrated plastic ruler.

For full TLC (Thin Layer Chromatography) instructions read our guide how to test drugs purity.

FENTANYL How to detect fentanyl?

What is fentanyl?

Fentanyl is an extremely potent and dangerous synthetic opioid, often mixed in street drugs and deadly.

BEFORE using a fentanyl test strip
  • It’s RECOMMENDED to test each and every dose. Because of extreme potency (microgram range) fentanyl is never evenly mixed in. One part of a baggie can be fentanyl free and another lethal.
How to test MEPHEDRONE?
How to test fentanyl powder / pills / spice with a fentanyl test strip?
  • Dissolve 100 mg in at least 125 ml of water (half a cup or at least 1 mg/ml).
  • Grab a test strip and insert the white end into the liquid, no higher than the thick line.
  • Wait until liquid starts visibly moving up the test strip (up to 15 seconds).
  • Put the test strip away on a flat dry surface and read the result in 2 minutes.
  • Check test strip result: a single line confirms the presence of fentanyl, while two lines (even faint) rule it out.

Fentanyl test did not react as indicated? Watch out!
All test results are available in our instructions and the TestDrugs app.

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FAQ Frequently Asked Questions

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