What is THC (Tetrahydrocannabinol)?

THC, which stands for tetrahydrocannabinol, is the main psychoactive compound found in the cannabis plant. It is the primary substance responsible for the psychedelic effects of using marijuana. This compound has a long history of recreational and medicinal use in various cultures over the centuries.

Cannabis flower with THC

Description and History of THC

The history of THC is closely tied to the history of the use of Indian hemp. This plant has been used for various purposes, from medicinal to recreational, in different cultures around the world. In the 20th century, it became a subject of controversy due to its psychoactive properties. Currently, THC is being researched for potential medical applications, such as pain relief, inflammation reduction, and even support in the treatment of certain neurological conditions.

VIDEO: Do's and don'ts of using weed (marijuana) (enable captions)

How Does THC Work?

THC is a chemical compound from the cannabinoid group that primarily affects the central nervous system by activating cannabinoid receptors. This leads to changes in neurological functions, impacting memory, thinking, sensory perception, and mood. THC is responsible for most of the psychoactive effects associated with marijuana, including feelings of euphoria, altered perception, and increased appetite.


THC: Effects

1. Euphoria and Relaxation: THC often induces feelings of euphoria and relaxation.
2. Altered Sensory Perception: THC users may experience altered sensory perception, especially regarding vision, hearing, and taste.
3. Increased Appetite: THC can lead to an increased appetite, commonly referred to as the “munchies” effect.
4. Decreased Coordination: THC users may experience reduced coordination and motor skills.
5. Mood Changes: THC can affect moods, causing both euphoria and anxiety or paranoia.
6. Potential Side Effects: Using THC carries the risk of side effects such as memory impairment, anxiety, and decreased cognitive abilities.
7. Risk of Addiction: THC can lead to psychological addiction and, in some cases, physical addiction, especially with long-term and regular use.
8. Potential Health Effects: Regular THC use can lead to adverse health effects, such as respiratory problems, memory issues, and mood changes.


THC: Duration of Effects

  • Onset of Effects: THC effects typically appear within a few minutes to half an hour after consumption.
  • Peak Effects: THC reaches its maximum effect usually within the first 2 hours after consumption.
  • Duration of Effects: THC effects can last from 2 to 4 hours, depending on the dose, method of consumption, and individual body response.
  • Wearing Off: After the period of action, users may experience a gradual decline, which can result in fatigue and a lowered mood.

THC: Dosage

  • Standard Dose: Typical THC dosage may vary depending on the method of consumption but is usually between 5 and 20 mg, depending on individual tolerance.
  • Low Dose: A dosage below 5 mg is considered low and may produce subtle psychoactive effects.
  • High Dose: Dosages above 20 mg can lead to stronger effects but carry a greater risk of side effects and health consequences.

VIDEO: How does THC works? (enable captions)

Damage Reduction: THC

Do not use THC, especially if:

  • You have a history of mental illnesses such as psychosis or schizophrenia.
  • You are taking medications that may have negative interactions with THC.
  • You are pregnant or breastfeeding.
  • You have a history of substance abuse.
  • You are in a dangerous environment where there is a risk of exposure to hazardous situations.

Here are some basic tips for damage reduction when using THC:

  • Start with a low dose, especially if you have no experience with using THC.
  • Remember to maintain hydration balance, avoiding excessive water intake.
  • Avoid frequent use of THC to prevent building tolerance and potential harmful effects on mental health.
  • Be cautious when combining THC with other substances that may affect your health.
  • In case of serious side effects, consult a doctor.
  • If you plan to use THC, make sure it is pure by using a reliable substance testing kit, such as the PRO Test. Learn how to conduct a THC test by reading the article available at

Click the article above to learn how to test THC and CBD or other cannabinoids.

Mixing: THC

It’s best to avoid mixing psychoactive substances, but if you do, it’s important to be aware of the potential risks. Here is a list of the main risks of mixing THC with popular psychoactive substances:


  • THC and Alcohol: Combining THC and alcohol may increase the risk of cognitive impairment and reduced psychophysical performance.
  • THC and Benzodiazepines: The combination can lead to increased sedative effects and the risk of excessive sedation.
  • THC and DMT: Combining THC with DMT can lead to enhanced psychedelic effects and potential disorientation.
  • THC and GBL: Combining THC with GBL carries an increased risk of consciousness disorders and overdose risk.
  • THC and GHB: Combining THC with GHB may increase the risk of consciousness disorders and overdose risk.
  • THC and Psilocybin Mushrooms: The combination can lead to the potential amplification of psychedelic effects and mood changes.
  • THC and Selective Serotonin Reuptake Inhibitors (SSRIs): Increased risk of side effects such as nausea and mood changes may occur.
  • THC and Ketamine: Combining THC with ketamine can lead to increased dissociative effects and disorientation.
  • THC and Caffeine: The combination may increase the risk of tachycardia and heightened excitability.
  • THC and MDMA: Combining THC with MDMA may increase the risk of uncontrolled euphoria and mood changes.
  • THC and LSD: The combination can lead to the potential amplification of psychedelic effects and mood changes.
  • THC and MAOIs: Combining THC with MAOIs carries a low risk.
  • THC and Methamphetamine: Concurrent use of THC and methamphetamine can overly stimulate the nervous system and increase health risks.
  • THC and NBOMe: Combining THC with NBOMe can lead to increased effects and the risk of excessive stimulation.
  • THC and Opioids: Mixing THC with opioids carries an increased risk of respiratory depression and overdose.
  • THC and Nitrous Oxide: The combination can lead to enhanced dissociative effects and disorientation.
  • THC and Amphetamines: Combining THC with amphetamines may increase the risk of anxiety and paranoia.
  • THC and Tramadol: Mixing THC with tramadol may carry the potential risk of dangerous interactions and side effects.

Is THC Legal?

The legal status of THC varies by country. In some jurisdictions, THC is legal for medical use, while in others, it is a controlled substance, and its recreational use is illegal.





The information presented on this page is not intended to promote drug use. Many of the substances mentioned are illegal according to national and international law, and possessing these substances is punishable by law. Never assume that a substance is safe. The concentration, purity, and additives can vary greatly, even if the samples come from the same source or look similar. Chemical Safety sp. z o.o. strongly discourages the use of any psychoactive substances – legal or illegal. Using psychoactive substances always carries health risks that can be avoided.